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Cited by 100Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryMesenchymal stem cell research

Modularized Extracellular Vesicles: The Dawn of Prospective Personalized and Precision Medicine

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Tao, Shi‐Cong, Guo, Shang‐Chun, Zhang, Chang‐Qing·2018·Advanced Science
DOI 10.1002/advs.201700449PMC PMC5827100
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Abstract

Extracellular vesicles (EVs) are ubiquitous nanosized membrane vesicles consisting of a lipid bilayer enclosing proteins and nucleic acids, which are active in intercellular communications. EVs are increasingly seen as a vital component of many biological functions that were once considered to require the direct participation of stem cells. Consequently, transplantation of EVs is gradually becoming considered an alternative to stem cell transplantation due to their significant advantages, including their relatively low probability of neoplastic transformation and abnormal differentiation. However, as research has progressed, it is realized that EVs derived from native-source cells may have various shortcomings, which can be corrected by modification and optimization. To date, attempts are made to modify or improve almost all the components of EVs, including the lipid bilayer, proteins, and nucleic acids, launching a new era of modularized EV therapy through the "modular design" of EV components. One high-yield technique, generating EV mimetic nanovesicles, will help to make industrial production of modularized EVs a reality. These modularized EVs have highly customized "modular design" components related to biological function and targeted delivery and are proposed as a promising approach to achieve personalized and precision medicine.

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Authors
Tao, S., Guo, S., & Zhang, C.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Department of Orthopaedic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital 600 Yishan Road Shanghai 200233 China
Corresponding author
Guo, Shang‐Chun
ORCID
Venue
Advanced Science
Publisher
Wiley
Published
2018-01-02
Volume
5
Issue
2
Pages
1700449-1700449
ISSN
2198-3844 (ISSN-L)
DOI
10.1002/advs.201700449
PMC
PMC5827100
OpenAlex
W2782167051
Cited by
100
References
152
Citations by year
2026: 3 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 18 · 2021: 15 · 2020: 14 · 2019: 12 · 2018: 9
FWCI
1.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Science (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Natural Science Foundation of China (81301589, 81472066)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
extracellular vesicles, targeted delivery, personalized medicine, precision medicine, intercellular communication

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