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Cited by 104Electrochemical sensors and biosensorsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection

Advances in Electrochemical Biosensors Based on Nanomaterials for Protein Biomarker Detection in Saliva

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Dong, Tao, Matos Pires, Nuno Miguel, Yang, Zhaochu, Jiang, Zhuangde·2023·Advanced Science
DOI 10.1002/advs.202205429PMC PMC9951322
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Abstract

The focus on precise medicine enhances the need for timely diagnosis and frequent monitoring of chronic diseases. Moreover, the recent pandemic of severe acute respiratory syndrome coronavirus 2 poses a great demand for rapid detection and surveillance of viral infections. The detection of protein biomarkers and antigens in the saliva allows rapid identification of diseases or disease changes in scenarios where and when the test response at the point of care is mandated. While traditional methods of protein testing fail to provide the desired fast results, electrochemical biosensors based on nanomaterials hold perfect characteristics for the detection of biomarkers in point‐of‐care settings. The recent advances in electrochemical sensors for salivary protein detection are critically reviewed in this work, with emphasis on the role of nanomaterials to boost the biosensor analytical performance and increase the reliability of the test in human saliva samples. Furthermore, this work identifies the critical factors for further modernization of the nanomaterial‐based electrochemical sensors, envisaging the development and implementation of next‐generation sample‐in‐answer‐out systems.

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  • High analytical sensitivity does not necessarily equal clinical diagnostic value unless disease-specific thresholds, workflow feasibility, and comparison with established diagnostic methods are validated.

    “In addition, high analytical sensitivity does not necessarily equal clinical diagnostic value unless disease-specific thresholds, workflow feasibility, and comparison with established diagnostic methods are validated.102”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [102]

    The Comparison of Electrochemical Sensors section (page unavailable) relates detection limits to clinically relevant biomarker concentrations, and Current Trends and Future Perspectives calls for population studies to confirm clinical usefulness and validate sensor responses. The Introduction and Conclusion also identify practical barriers to rapid, usable tests. Our copy does not establish that disease-specific diagnostic thresholds and comparison with established diagnostic methods must be validated, so the full list of requirements is not supported. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Dong, T., Matos Pires, N. M., Yang, Z., & Jiang, Z.
Affiliations
  • University of South-Eastern Norway (NO)
  • Chongqing Key Laboratory of Micro‐Nano Systems and Intelligent Transduction Collaborative Innovation Center on Micro‐Nano Transduction and Intelligent Eco‐Internet of Things Chongqing Key Laboratory of Colleges and Universities on Micro‐Nano Systems Technology and Smart Transducing National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business University Nan'an District Chongqing 400067 China
  • Chongqing Technology and Business University (CN)
Corresponding author
Dong, Tao
ORCID
Venue
Advanced Science
Publisher
Wiley
Published
2022-12-30
Volume
10
Issue
6
Pages
e2205429-e2205429
ISSN
2198-3844 (ISSN-L)
DOI
10.1002/advs.202205429
PMC
PMC9951322
OpenAlex
W4313340181
Cited by
104
References
190
Citations by year
2026: 20 · 2025: 34 · 2024: 37 · 2023: 12 · 2022: 1
FWCI
1.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Chongqing Municipal Education Commission
  • National Natural Science Foundation of China (82150410457)
  • Chongqing Basic and Frontier Research Project (cstc2021jcyj‐msxmX0920)
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Keywords
electrochemical biosensor, nanomaterials, saliva, point-of-care testing, rapid antigen detection, COVID-19 detection, chronic disease monitoring, viral infection surveillance
MeSH terms
COVID-19, Humans, Saliva, Reproducibility of Results, Biosensing Techniques, Biomarkers, Nanostructures, Electrochemical Techniques

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