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Drug permeation through human skin: Theory and invitro experimental measurement
Abstract
The penetration of drugs and other micromolecules through intact human skin can be regarded as a process of dissolution and molecular diffusion through a composite, multilayer membrane, whose principal barrier to transport is localized within the stratum corneum. A mathematical model of the stratum corneum as a two‐phase protein‐lipid heterogeneous membrane (in which the lipid phase is continuous) correlates the permeability of the membrane to a specific penetrant with the water solubility of the penetrant and with its lipid‐protein partition coefficient. Experimentally measured permeabilities of human skin to a variety of drugs have been found to conform to this model. The extraordinarily low permeability of skin to most micromolecules appears to arise from the very low diffusivity of such molecules in the intercellular lipid phase.
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Cited by
Nanoparticles and microparticles for skin drug delivery
Prow, T. W., Grice, J. E., Lin, L. L., Faye, R., Butler, M., Becker, W., Wurm, E. M. T., Yoong, C., Robertson, T. A., Soyer, H. P., et al. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.012 · Cited by 873
Nanoparticles skin absorption: New aspects for a safety profile evaluation
Larese Filon, F., Mauro, M., Adami, G., Bovenzi, M., & Crosera, M. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.05.005 · Cited by 390
van Smeden, J., & Bouwstra, J. A. (2016) · Current Problems in Dermatology · doi:10.1159/000441540 · Cited by 366
Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities
Neupane, R., Boddu, S. H. S., Renukuntla, J., Babu, R. J., & Tiwari, A. K. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020152 · Cited by 351
INVITED REVIEW POLYMERIC DELIVERY SYSTEMS FOR CONTROLLED DRUG RELEASE
LANGER, R. (1980) · Chemical Engineering Communications · doi:10.1080/00986448008912519 · Cited by 288
Metadata
- Authors
- Michaels, A. S., Chandrasekaran, S. K., & Shaw, J. E.
- Venue
- AIChE Journal
- Publisher
- Wiley
- Published
- 1975-09
- Volume
- 21
- Issue
- 5
- Pages
- 985-996
- ISSN
- 0001-1541 (ISSN-L)
- 1547-5905
- OpenAlex
- W2172187417
- Cited by
- 801
- References
- 0
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Drug permeation through human skin: Theory and invitro experimental measurement. https://app.cochat.ai/papers/10.1002/aic.690210522
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- Michaels, A. S., Chandrasekaran, S. K., & Shaw, J. E. (1975). Drug permeation through human skin: Theory and invitro experimental measurement. AIChE Journal. https://doi.org/10.1002/aic.690210522
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
