Psychiatric disability associated with the fragile X chromosome
Abstract
Fragile X (or Martin‐Bell) syndrome, a common, genetic, mental retardation disorder is increasingly being recognized as a major cause of cognitive disability and psychiatric illness in boys. Here, we present a study in which relatives in 4 generations of a large family with the fra(X) chromosome were given comprehensive psychiatric evaluations in order to further describe the psychopathology associated with this condition. Three of 4 males with the fra(X) chromosome were found to have autistic behavior. An adult fra(X) male had a chronic schizoaffective disorder and mental retardation. In femal relatives, a relationship was found between the fra(X) carrier status and psychopathology including schizoaffective and major affective disorders.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mutations in the CYFIP1 network might explain part of the autistic features observed in FXS patients.
“Our findings suggest that mutations in the CYFIP1 network might explain part of the autistic features observed in FXS patients (Farzin et al., 2006), which can also suffer from psychosis (Reiss et al., 1986).”
From CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation (2013) · cites this paper as Reiss et al., 1986
Cited by
Sorted by citations
De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.039 · Cited by 296 · see citing works
- Authors
- Reiss, A. L., Feinstein, C., Goldsmith, K. E. T. B., Rosenbaum, K., Caruso, M. A., Opitz, J. M., & Reynolds, J. F.
- Affiliations
- Children's National (US)
- Corresponding author
- Reiss, A. L.
- Venue
- American Journal of Medical Genetics
- Publisher
- Wiley
- Published
- 1986-01
- Volume
- 23
- Issue
- 1-2
- Pages
- 393-401
- ISSN
- 0148-7299 (ISSN-L)
- 1096-8628
- OpenAlex
- W1963621449
- Cited by
- 52
- References
- 0
- Citations by year
- 2013: 1
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- fragile X syndrome, psychiatric disability, intellectual disability, autism spectrum disorder, schizoaffective disorder, mood disorders, carrier state, family studies, psychopathology
- MeSH terms
- Adolescent, Adult, Aged, Autistic Disorder, Mental Disorders, Bipolar Disorder, Child, Depressive Disorder, Female, Fragile X Syndrome, Heterozygote, Humans, Male, Middle Aged, Pedigree, Psychotic Disorders, Schizophrenia, Sex Chromosome Aberrations, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
