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Limb deficiency with or without Möbius sequence in seven Brazilian children associated with misoprostol use in the first trimester of pregnancy
Abstract
Misoprostol, a synthetic analog of prostaglandin, has been widely used in Brazil as an abortifacient. Abortion is illegal in Brazil. An uncertain number of these abortion attempts are unsuccessful and the pregnancy continues. We report on 7 patients whose mothers attempted to abort using this drug in the first trimester of gestation without success. The 7 patients presented with limb defects and in 4 of them a diagnosis of Möbius sequence was made. © 1993 Wiley‐Liss, Inc.
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Citations
Cited by
Microtia: Epidemiology and genetics
Luquetti, D. V., Heike, C. L., Hing, A. V., Cunningham, M. L., & Cox, T. C. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34352 · Cited by 457
Early Pregnancy Termination with Mifepristone and Misoprostol in the United States
Spitz, I. M., Bardin, C. W., Benton, L., & Robbins, A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804303381801 · Cited by 441
Use of Misoprostol during Pregnancy and Möbius' Syndrome in Infants
Pastuszak, A. L., Schüler, L., Speck-Martins, C. E., Coelho, K.-E. F. A., Cordello, S. M., Vargas, F., Brunoni, D., Schwarz, I. V. D., Larrandaburu, M., Safattle, H., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806253382604 · Cited by 272
Self-citationPrenatal factors associated with autism spectrum disorder (ASD)
Ornoy, A., Weinstein-Fudim, L., & Ergaz, Z. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.05.007 · Cited by 238
Randomised trial comparing expectant with medical management for first trimester miscarriages
Nielsen, S., Hahlin, M., & Platz‐Christensen, J. (1999) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1999.tb08401.x · Cited by 126
Metadata
- Authors
- Gonzalez, C. H., Vargas, F. R., Perez, A. B. A., Kim, C. A., Brunoni, D., Marques‐Dias, M. J., Leone, C. R., Neto, J. C., Llerena, J. C., & de Almeida, J. C. C.
- Venue
- American Journal of Medical Genetics
- Publisher
- Wiley
- Published
- 1993-08
- Volume
- 47
- Issue
- 1
- Pages
- 59-64
- ISSN
- 0148-7299 (ISSN-L)
- 1096-8628
- OpenAlex
- W2000011246
- Cited by
- 186
- References
- 0
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Limb deficiency with or without Möbius sequence in seven Brazilian children associated with misoprostol use in the first trimester of pregnancy. https://app.cochat.ai/papers/10.1002/ajmg.1320470113
- The paper
- Gonzalez, C. H., Vargas, F. R., Perez, A. B. A., Kim, C. A., Brunoni, D., Marques‐Dias, M. J., Leone, C. R., Neto, J. C., Llerena, J. C., & de Almeida, J. C. C. (1993). Limb deficiency with or without Möbius sequence in seven Brazilian children associated with misoprostol use in the first trimester of pregnancy. American Journal of Medical Genetics. https://doi.org/10.1002/ajmg.1320470113
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
