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Craniofacial defects of blastogenesis: Duplication of pituitary with cleft palate and orophgaryngeal tumors
Abstract
Duplications of organs and/or tissues are rare in morphogenesis and have frequently been attributed to incomplete twinning. To further elucidate the phenotypes associated with organ duplications, we present three infants with duplication of the pituitary gland (DPG). A review of previously reported cases with DPG showed that the commonest additional findings were hypothalamic enlargement, a broad or duplicated sella, cleft palate, hypertelorism, oropharyngeal tumors, agenesis or hypoplasia of the corpus callosum, and abnormalities of vertebrae. DPG and additional malformations constitute a distinct and recognizable pattern of anomalies, which may constitute a polytopic field defect due to splitting of the notochord. However, the precise inductive mechanism resulting in DPG remains unknown. © 2005 Wiley‐Liss, Inc.
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“Abnormal thickening, “pseudohamartoma”, of the hypothalamus with duplication of the infundibular recess of the third ventricle is often seen [16, 18].”
From Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review (2015) · cites this paper as [16]
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“MRI findings include duplicated pituitary stalks and glands within separate pituitary fossa in the sphenoid bone.”
From Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review (2015) · cites this paper as [16]
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Research works printed but not linked: 33
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Cited by
Shields, R., Mangla, R., Almast, J., & Meyers, S. (2015) · Insights into Imaging · doi:10.1007/s13244-015-0401-5 · Cited by 18
Metadata
- Authors
- Slavotinek, A., Parisi, M., Heike, C., Hing, A., & Huang, E.
- Venue
- American Journal of Medical Genetics Part A
- Publisher
- Wiley
- Published
- 2005-04-04
- Volume
- 135A
- Issue
- 1
- Pages
- 13-20
- ISSN
- 1552-4825
- 1552-4833
- Cited by
- 34
- References
- 0
- Language
- en
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