Chromosome 11‐q24 region in Tourette syndrome: Association and linkage disequilibrium study in the French Canadian population
Abstract
Previous studies have found association and linkage between Tourette syndrome (TS) and markers at the 11q24 region, mainly with markers D11S1377 and D11S933. In order to determine if these positive findings could be replicated in our sample, we undertook a family‐based association study in 199 French Canadian TS nuclear families. We genotyped 572 individuals from 174 complete and 25 incomplete TS trios. TDT analysis failed to detect an association between TS and six markers from 11q24. Furthermore, no haplotype combining alleles from D11S1377, D11S933, or any of the other four markers was associated with the disorder. Linkage disequilibrium analysis showed evidence of historical recombination between every contiguous pair of markers, indicating that these genetic variants are probably in equilibrium in the French Canadian population. Further analysis in additional families, with different methodologies (linkage and association) will be required in order to determine if the 11q24 region harbors a susceptibility locus for TS. If it does, this defect may not be frequent in the French Canadian population due to locus heterogeneity. © 2005 Wiley‐Liss, Inc.
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Variants in the DA receptor gene DRD2 have been associated with genetic risk for TS, but this finding is not consistent.
“Variants in the DA receptor gene DRD2 have also been associated with genetic risk for TS [626-628], but this finding is not consistent [629-633].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [630]
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References 13 · Cited by 11
- Authors
- Díaz‐Anzaldúa, A., Rivière, J., Dubé, M., Joober, R., Saint‐Onge, J., Dion, Y., Lespérance, P., Richer, F., Chouinard, S., Rouleau, G. A., & The Montreal Tourette Syndrome Study Group
- Affiliations
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Centre Hospitalier de l’Université de Montréal (CA)
- Montreal Heart Institute (CA)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Rouleau, Guy Armand
- ORCID
- Venue
- American Journal of Medical Genetics Part A
- Publisher
- Wiley
- Published
- 2005-09-20
- Volume
- 138A
- Issue
- 3
- Pages
- 225-228
- ISSN
- 1552-4825 (ISSN-L)
- 1552-4833
- OpenAlex
- W2070438340
- Cited by
- 11
- References
- 13
- Citations by year
- 2019: 2 · 2017: 1 · 2016: 1 · 2012: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part A (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Tourette syndrome, linkage disequilibrium, family-based association, haplotype analysis, French-Canadian population, locus heterogeneity, genetic susceptibility loci, genetic recombination
- MeSH terms
- Adolescent, Canada, Chromosome Mapping, Chromosomes, Human, Pair 11, Genetic Markers, Tourette Syndrome, Haplotypes, Humans, Quebec, Linkage Disequilibrium
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