The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Lipedema: An inherited condition
Abstract
Lipedema is a condition characterized by swelling and enlargement of the lower limbs due to abnormal deposition of subcutaneous fat. Lipedema is an under‐recognized condition, often misdiagnosed as lymphedema or dismissed as simple obesity. We present a series of pedigrees and propose that lipedema is a genetic condition with either X‐linked dominant inheritance or more likely, autosomal dominant inheritance with sex limitation. Lipedema appears to be a condition almost exclusively affecting females, presumably estrogen‐requiring as it usually manifests at puberty. Lipedema is an entity distinct from obesity, but may be wrongly diagnosed as primary obesity, due to clinical overlap. The phenotype suggests a condition distinct from obesity and associated with pain, tenderness, and easy bruising in affected areas. © 2010 Wiley‐Liss, Inc.
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Cites
PATTERNED LOSS OF HAIR IN MAN: TYPES AND INCIDENCE
Hamilton, J. B. (1951) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1951.tb31971.x · Cited by 994
Shenker, A., Laue, L., Kosugi, S., Merendino, J. J., Minegishi, T., & Cutler, G. B. (1993) · Nature · doi:10.1038/365652a0 · Cited by 745
Rook's Textbook of Dermatology
McColl, I. (2005) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.2005.00184.x · Cited by 516
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
Dibbens, L. M., Tarpey, P. S., Hynes, K., Bayly, M. A., Scheffer, I. E., Smith, R., Bomar, J., Sutton, E., Vandeleur, L., Shoubridge, C., et al. (2008) · Nature Genetics · doi:10.1038/ng.149 · Cited by 451
Epilepsy and mental retardation limited to females: an X-linked dominant disorder with male sparing
Ryan, S. G., Chance, P. F., Zou, C., Spinner, N. B., Golden, J. A., & Smietana, S. (1997) · Nature Genetics · doi:10.1038/ng0997-92 · Cited by 128
Testicular Leydig Cell Hyperplasia as a Cause of Familial Sexual Precocity*
Schedewie, H., Reiter, E. O., Beitins, I. Z., SEYED, S., WOOTEN, V. D., Jimenez, J. F., Aiman, E. J., DeVane, G. W., Redman, J. F., & Elders, M. J. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-2-271 · Cited by 126
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Skin changes in the obese patient
Hirt, P. A., Castillo, D. E., Yosipovitch, G., & Keri, J. E. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.12.070 · Cited by 182
Metadata
- Authors
- Child, A. H., Gordon, K. D., Sharpe, P., Brice, G., Ostergaard, P., Jeffery, S., & Mortimer, P. S.
- Venue
- American Journal of Medical Genetics Part A
- Publisher
- Wiley
- Published
- 2010-03-26
- Volume
- 152A
- Issue
- 4
- Pages
- 970-976
- ISSN
- 1552-4825 (ISSN-L)
- 1552-4833
- OpenAlex
- W2031874127
- Cited by
- 329
- References
- 6
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Child, A. H., Gordon, K. D., Sharpe, P., Brice, G., Ostergaard, P., Jeffery, S., & Mortimer, P. S. (2010). Lipedema: An inherited condition. American Journal of Medical Genetics Part A. https://doi.org/10.1002/ajmg.a.33313
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