Cranial neural crest cells on the move: Their roles in craniofacial development
Open accessAbstract
The craniofacial region is assembled through the active migration of cells and the rearrangement and sculpting of facial prominences and pharyngeal arches, which consequently make it particularly susceptible to a large number of birth defects. Genetic, molecular, and cellular processes must be temporally and spatially regulated to culminate in the three‐dimension structures of the face. The starting constituent for the majority of skeletal and connective tissues in the face is a pluripotent population of cells, the cranial neural crest cells (NCCs). In this review we discuss the newest scientific findings in the development of the craniofacial complex as related to NCCs. Furthermore, we present recent findings on NCC diseases called neurocristopathies and, in doing so, provide clinicians with new tools for understanding a growing number of craniofacial genetic disorders. © 2010 Wiley‐Liss, Inc.
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Cranial neural crest cells are the main contributors to the development of the facial skeleton.
“the main contributors to the development of the facial skeleton 2”
From The evolutionary history of the human face (2019) · cites this paper as [2]
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References 124 · Cited by 305
- Authors
- Cordero, D. R., Brugmann, S., Chu, Y., Bajpai, R., Jame, M., & Helms, J. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Stanford Medicine (US)
- Corresponding author
- Cordero, Dwight R.
- Venue
- American Journal of Medical Genetics Part A
- Publisher
- Wiley
- Published
- 2010-12-10
- Volume
- 155
- Issue
- 2
- Pages
- 270-279
- ISSN
- 1552-4825 (ISSN-L)
- 1552-4833
- PMC
- PMC3039913
- OpenAlex
- W2001237524
- Cited by
- 305
- References
- 124
- Citations by year
- 2026: 24 · 2025: 24 · 2024: 21 · 2023: 28 · 2022: 19 · 2021: 27 · 2020: 24 · 2019: 18 · 2018: 23 · 2017: 20 · 2016: 13 · 2015: 12 · 2014: 20 · 2013: 16 · 2012: 14
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Medical Genetics Part A (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (K99DE019853)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD001255)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Cleft Lip and Palate Research
- Keywords
- cranial neural crest cells, craniofacial development, cell migration, facial prominences, branchial arches, congenital craniofacial anomalies, neurocristopathy
- MeSH terms
- Cell Differentiation, Cell Movement, Humans, Neural Crest, Skull, Signal Transduction, Craniofacial Abnormalities, Body Patterning, Cell Proliferation
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