Confirming RGS4 as a susceptibility gene for schizophrenia
Abstract
A recent study identified a putative association between variants in the regulator of G-protein signalling 4 (RGS4) and schizophrenia, Chowdari et al. [2002: Hum Mol Genet 11: 1373-1380]. RGS4 is both a positional and functional candidate gene for schizophrenia. Chowdari and colleagues identified association at this locus in a number of distinct and ethnically diverse samples, although the pattern of association was not the same in all the samples. Our study attempted to replicate this association in an independent Irish sample of schizophrenia cases and controls. We succeeded in detecting evidence of association at the RGS4 locus. The signal comes from a four-marker haplotype that is in significant excess in our case sample. The same haplotype is in excess in the Caucasian schizophrenia sample used by Chowdari et al. [2002: Hum Mol Genet 11: 1373-1380]. This study provides further support for the contribution of RGS4 to schizophrenia susceptibility.
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RGS4 levels are greatly reduced in the PFC of patients with schizophrenia, and there is evidence of genetic alterations in RGS4 in some families with schizophrenia or bipolar disorder.
“RGS4 levels are greatly reduced in the PFC of patients with schizophrenia134,135, and there is evidence of genetic alterations in RGS4 in some families with schizophrenia or bipolar disorder136,137.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [137]
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- Authors
- Morris, D. W., Rodgers, A., McGhee, K. A., Schwaiger, S., Scully, P., Quinn, J., Meagher, D., Waddington, J. L., Gill, M., & Corvin, A. P.
- Affiliations
- Trinity College Dublin (IE)
- St. Davnet's Hospital (IE)
- Royal College of Surgeons in Ireland (IE)
- Corresponding author
- Morris, Derek W.
- ORCID
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2003-09-05
- Volume
- 125B
- Issue
- 1
- Pages
- 50-53
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2050787008
- Cited by
- 137
- References
- 12
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- RGS4, schizophrenia, genetic susceptibility, genetic association, haplotypes, G protein signaling, replication study, Irish population
- MeSH terms
- Disease Susceptibility, Genetic Markers, Haplotypes, Humans, Schizophrenia, Linkage Disequilibrium, Polymorphism, Single Nucleotide, RGS Proteins
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