The BDNF Val66Met × 5‐HTTLPR × child adversity interaction and depressive symptoms: An attempt at replication
Abstract
Kaufman et al. [2006] reported a higher order interaction effect between specific genetic and environmental factors in a model of depressive symptoms, requiring independent replication. BDNF Val(66)Met and 5-HTTLPR genotypes were determined in female participants pertaining to a large ongoing twin study. Participants also filled in questionnaires on childhood adversity and depressive symptoms. Two- and three-way interactions between genetic polymorphisms and early adversity were examined in models of depressive symptoms. BDNF Met allele(s) moderated the effect of early adversity on depressive symptoms (two-way interaction), and this BDNF Met x childhood adversity interaction in turn was moderated by 5-HTTLPR genotype (three-way interaction). However, a main effect of BDNF Met on childhood adversity was also observed, possibly indicating confounding by gene-environment correlation. Higher order interaction effects involving BDNF Val(66)Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness.
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Wichers et al. (2008) identified a three-way interaction between early life stress, 5-HTTLPR, and BDNF, but also found rGE between BDNF genotype and reported childhood adversity, with increased adversity reported by Val/Met relative to Val/Val youth.
“Wichers et al. (2008), identified a three-way interaction between ELS, 5-HTTLPR, and BDNF, which the authors acknowledged must be qualified by the fact that they also found rGE between BDNF genotype and reported childhood adversity (with increased adversity reported by youth with Val/Met relative to Val/Val).”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Wichers et al. (2008)
Kaufman et al. (2006) and Wichers et al. (2008) demonstrated that BDNF Val66Met acts as a moderator of 5-HTTLPR×ELS interactions.
“As discussed above, the studies by Kaufman et al. (2006) and Wichers et al. (2008) demonstrate that BDNF Val66Met acts as a moderator of 5-HTTLPR×ELS interactions.”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Wichers et al. (2008)
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References 13 · Cited by 127
- Authors
- Wichers, M., Kenis, G., Jacobs, N., Mengelers, R., Derom, C., Vlietinck, R., & van Os, J.
- Affiliations
- Maastricht University (NL)
- KU Leuven (BE)
- Corresponding author
- Wichers, Marieke
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2007-06-19
- Volume
- 147B
- Issue
- 1
- Pages
- 120-123
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W1993880932
- Cited by
- 127
- References
- 13
- Citations by year
- 2020: 2 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 12 · 2015: 10 · 2014: 12 · 2013: 12 · 2012: 14
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- BDNF Val66Met polymorphism, 5-HTTLPR, childhood adversity, depressive symptoms, gene-environment interaction, gene-environment correlation, twin studies, replication, female participants, etiology of depression
- MeSH terms
- Adolescent, Adult, Alleles, Depression, DNA Mutational Analysis, Environment, Female, Genotype, Humans, Male, Methionine, Middle Aged, Surveys and Questionnaires, Valine, Genetic Variation, Brain-Derived Neurotrophic Factor, Serotonin Plasma Membrane Transport Proteins
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