The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies

Philibert, Robert A., Sandhu, Harinder, Hollenbeck, Nancy, Gunter, Tracy, Adams, William, Madan, Anup·2008·American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
DOI 10.1002/ajmg.b.30657

Cited by (300)

Items 201–300 of 300

  1. Multi-adaptive Neural Modelling of the Interplay of Changing Organisational Contexts, Epigenetics, and Personality Traits in the Development of Burnout
    Debby Bouma, Jan Treur A · 2024 · IFIP advances in information and communication technology
  2. Transcriptional Regulators as Targets for Alcohol Pharmacotherapies
    Antonia M. Savarese, Amy W. Lasek · 2018 · Handbook of experimental pharmacology
  3. Sex-dependent DNA hypermethylation of SLC6A4 in patients with schizophrenia
    Linlin Liu, Yi Hu, Yumei Lu, Liping Hu, Chang‐Qing Gao, Shengjie Nie · 2021 · Neuroscience Letters
  4. Genetic moderation of the association between adolescent romantic involvement and depression: Contributions of serotonin transporter gene polymorphism, chronic stress, and family discord
    Lisa R. Starr, Constance L. Hammen · 2015 · Development and Psychopathology
  5. Additive serotonergic genetic sensitivity and cortisol reactivity to lab-based social evaluative stress: Influence of severity across two samples
    Suzanne Vrshek‐Schallhorn, Gail M. Corneau, Alessandra R. Grillo, Vaibhav R. Sapuram, Thomas Plieger, Martin Reuter · 2022 · Psychoneuroendocrinology
  6. Prediction of deleterious non-synonymous single nucleotide polymorphisms of genes related to ethanol-induced toxicity
    Linlin Wang, Yong Li, Shufeng Zhou · 2009 · Toxicology Letters
  7. Methylation of the serotonin reuptake transporter gene and non-motor symptoms in dystonia patients
    Elze R. Timmers, Torsten Plösch, Marenka Smit, Ingrid H. Hof, Rikst Nynke Verkaik‐Schakel, Marina A.J. Tijssen, Tom J. de Koning, Klary E. Niezen‐Koning · 2022 · Clinical Epigenetics
  8. Gut microbiome-derived metabolites and epigenetic modulation as potential countermeasures to acute stress
    Ruqaiyyah Siddiqui, David Lloyd, Sutherland Kester Maciver, Naveed Ahmed Khan · 2025 · Discover Medicine
  9. Testing bidirectional relationships between alcohol use and depressive symptoms: What is the role of the serotonin transporter gene?
    Roy Otten, Carmen S. van der Zwaluw, Rutger C. M. E. Engels · 2017 · Alcohol
  10. Pharmacogenetic Testing in Schizophrenia and Posttraumatic Stress Disorder
    Bronwyn Ramey-Hartung, Rifaat S. El-Mallakh, Kristen K. Reynolds · 2008 · Clinics in Laboratory Medicine
  11. Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence
    Christine Muench, Audrey C. Luo, Katrin Charlet, Jisoo Lee, Daniel B. Rosoff, Hui Sun, Samantha J. Fede, Jeesun Jung, Reza Momenan, Falk W. Lohoff · 2019 · Alcohol and Alcoholism
  12. Genetic Organization of the Serotonergic System
    Ursula M. D’Souza, Ian Craig · 2010 · Handbook of behavioral neuroscience
  13. Neurobiological correlates of burnout
    Avinash De Sousa, Durva Balkrishna Sail · 2021 · Telangana Journal of Psychiatry
  14. Serotonin transporter gene methylation and emotional regulation in preschool children born preterm: A longitudinal evaluation of the role of negative emotionality in infancy
    Eleonora Mascheroni, Paola Schiavolin, Isabella Lucia Chiara Mariani Wigley, Roberto Giorda, Uberto Pozzoli, Francesco Morandi, Camilla Fontana, Fabio Mosca, Monica Fumagalli, Rosario Montirosso · 2022 · Infant Mental Health Journal
  15. Gender differences in the genetic and environmental determinants of adolescent depression
    Monica Uddin, Karestan Chase Koenen, Regina de los Santos, Erin Bakshis, Allison E. Aiello, Sandro Galea · 2010 · Comprehensive Psychiatry
  16. An Overview of Machine Learning Applications in Mood Disorders
    Natasha Topolski, Su Hyun Jeong, Benson Mwangi · 2021 · Cambridge University Press eBooks
  17. The 5-HTTLPR-rs25531 S-A-S-A Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda
    Allan Kalungi, Jacqueline Samantha Womersley, Eugene Kinyanda, Moses Lutaakome Joloba, Wilber Joseph Ssembajjwe, Rebecca Namugabwe Nsubuga, Soraya Seedat, Sian M. J. Hemmings · 2021 · Frontiers in Genetics
  18. Epigenetics of Psychopathology
    Alicia K. Smith, Sasha E. Parets, Andrew Wooyoung Kim · 2014 · Springer eBooks
  19. 5‐ HTTLPR Moderates Naltrexone and Psychosocial Treatment Responses in Heavy Drinking Men Who Have Sex with Men
    Andrew C. H. Chen, Christine M. Davis, Christopher W. Kahler, Alexis Kuerbis, Jonathan Covault, Henry R. Kranzler, Jon Morgenstern · 2014 · Alcoholism Clinical and Experimental Research
  20. Epigenetics of Major Depressive Disorder
    Kevin Z. Wang, Oluwagbenga O. Dada, Ali Bani‐Fatemi, Samia Tasmim, Marcellino Monda, Ariel Graff, Vincenzo De Luca · 2019 · Elsevier eBooks
  21. Neurogenetics Approaches to Mapping Pathways in Developmental Psychopathology
    Luke Williamson Hyde, Johnna R. Swartz, Rebecca E. Waller, Ahmad R. Hariri · 2016 · Wiley eBooks
  22. Dopamine and Serotonin Transporter Genes Regulation in Highly Sensitive Individuals during Stressful Conditions: A Focus on Genetics and Epigenetics
    Claudio D’Addario, Fabio Bellia, Alessandro Piccinini, Loreta Cannito, Francesca Lionetti, Bernardo Maria Dell’Osso, Bernardo Maria Dell’Osso, Walter Adriani, Alberto Di Domenico, Alberto Di Domenico et al. · 2024 · Biomedicines
  23. Serotonin Transporter Gene Polymorphisms Predict Adherence to Weight Loss Programs Independently of Obesity-Related Genes
    Mana Yatsuda, Miyako Furou, Keiko Kamachi, Kaori Sakamoto, Kumiko Shoji, Osamu Ishihara, Yasuo Kagawa · 2025 · Nutrients
  24. Mood Disorders
    2021 · Cambridge University Press eBooks
  25. Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats
    Agata Cieslik-Starkiewicz, Karolina Noworyta, Joanna Solich, Agata Korlatowicz, Agata Faron‐Górecka, Rafał Ryguła · 2024 · Pharmacological Reports
  26. DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction?
    Giampiero Ferraguti, Silvia Francati, Claudia Codazzo, Giovanna Blaconà, Giancarlo Testino, Antonio Angeloni, Marco Fiore, Mauro Ceccanti, Marco Lucarelli · 2024 · International Journal of Molecular Sciences
  27. Functional Magnetic Resonance Imaging in Developmental Psychopathology: The Brain as a Window into the Development and Treatment of Psychopathology
    Johnna R. Swartz, Christopher S. Monk · 2014 · Springer eBooks
  28. Validation of serotonin transporter mRNA as a quantitative biomarker of heavy drinking and its comparison to ethyl glucuronide/ethyl sulfate: A randomized, double‐blind, crossover trial
    Jessica L. Cornell, Andrew Conchas, Xin‐Qun Wang, Jeffrey Craig Fink, Hegang Chen, Maureen A. Kane, Nageswara R. Pilli, Nassima Ait‐Daoud, David A. Gorelick, Ming D. Li et al. · 2022 · Alcoholism Clinical and Experimental Research
  29. Longitudinal DNA methylation in parent–infant pairs impacted by intergenerational social adversity: An RCT of the Michigan Model of Infant Mental Health Home Visiting
    Rebekah Petroff, Jennifer M. Jester, Jessica L. Riggs, Emily A. Alfafara, Katherine Springer, Natalie Kerr, Meriam Issa, Alanah Hall, Katherine Lisa Rosenblum, Jaclyn M. Goodrich et al. · 2024 · Brain and Behavior
  30. Alcohol and the Brain
    Ketan K. Marballi, Igor Ponomarev, Roy Dayne Mayfield, R. Adron Harris · 2014 · Elsevier eBooks
  31. Neuroimaging Studies of Effects of Psychotherapy in Depression
    Isabelle E. Bauer, Thomas Daniel Meyer · 2021 · Cambridge University Press eBooks
  32. Association between 5-HT1A receptor C-1019G, 5-HTTLPR polymorphisms and panic disorder: a meta-analysis
    Wenli Zhu, Yangying Bu, Lijuan Wu, Junwei Li, Chuanfu Song, Yihui Hao · 2024 · Aging
  33. Epigenetics in persons living with HIV: trauma, coping, and FKBP5 and SLC6A4 methylation
    Cassidy J. Tomlinson, Laura Ryniker, Haley M. Cook, Rebecca M. Schwartz, Amy L. Non · 2025 · Epigenomics
  34. Gene Expressions Associated with Neurotransmitter Metabolism in Children with Attention Deficit Hyperactivity Disorder
    Hilal Akalın, Yakut Erdem, Recep Eröz, İzem Olcay Şahin, Nuriye Gökçe, Sevgi Özmen, Muhammet Ensar Doğan, Munis Dündar, Yusuf Özkul · 2025 · Meandros Medical And Dental Journal
  35. Genetic, Epigenetic and Environmental Factors in Serotonin Associated Disease Condition
    Eva Friedel, Andreas Heinz · 2010 · Handbook of behavioral neuroscience
  36. DNA Methylation Across the Serotonin Transporter Gene Following Marital Separation: A Pilot Study
    David A. Sbarra, Chelsea Claire Cook, Karen Hasselmo, Muhammad S. Noon, Matthias R. Mehl · 2019 · Annals of Behavioral Medicine
  37. Trauma and Gene Expression: Understanding the Connections
    Stefanie R. Pilkay, Terri D. Combs-Orme · 2020 · Social Work Research
  38. Addictions et comorbidités
    Mickaël Naassïla · 2014 · Dunod eBooks
  39. Electrophysiological Biomarkers for Mood Disorders
    Nithya Ramakrishnan, Nicholas Murphy, Sudhakar Selvaraj, Raymond Y. Cho · 2021 · Cambridge University Press eBooks
  40. Association Study on Multi‐Timepoint DNA Methylation Levels of Serotonin Transporter Gene and Adolescent Psychological‐Behavioral Development
    Tempei Ikegame, Miki Bundo, Daiki Nagaoka, Yutaro Yanagida, Yutaka Nakachi, Emi Kiyota, Naohiro Okada, Shinsuke Koike, Syudo Yamasaki, Shuntaro Ando et al. · 2025 · Neuropsychopharmacology Reports
  41. Longitudinal associations of DNA-methylation of OXT, SLC6A4 and NR3C1 genes with the treatment response in patients with depression
    Simon Sanwald, Thomas Kammer, Bernhard J. Connemann, Christian Montag, Markus Kiefer · 2026 · Scientific Reports
  42. Neuroquantum Theories of Psychiatric Genetics: Can Physical Forces Induce Epigenetic Influence on Future Genomes?
    Kenneth Blum, Eric R. Braverman, Roger L. Waite, Trevor Archer, Peter K. Thanos, Rajendra Dhar Badgaiyan, Marcelo Febo, Kristina Dushaj, Mona Li, Mark S. Gold · 2015 · NeuroQuantology
  43. The Light Side of Preterm Behavioral Epigenetics
    Livio Provenzi, Renato Borgatti, Rosario Montirosso · 2016 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
  44. The digestion and dietary carbohydrate pathway contains 100% gene mutations enrichment among 117 patients with major depressive disorder
    Ni Zhang, Li Jin, Zaiquan Dong, Yongbo Hu, Zhihui Zhong, Qiyong Gong, Weihong Kuang · 2024 · Frontiers in Psychiatry
  45. Stress, Mood, and Pathways to Depression
    K. Ranga Krishnan · 2016 · Elsevier eBooks
  46. The Developmental Neuroepigenetics of Substance Abuse
    Briana Mason, S. Tiffany Donaldson, Richard G Hunter · 2018 · Journal of Drug and Alcohol Research
  47. Brain Imaging and the Mechanisms of Antidepressant Action
    Beata R. Godlewska, Sudhakar Selvaraj, Philip J. Cowen · 2021 · Cambridge University Press eBooks
  48. Effects of Lithium on Brain Structure in Bipolar Disorder
    Jasmine Kaur, Vivian Kafantaris, Philip R. Szeszko · 2021 · Cambridge University Press eBooks
  49. Functional Connectome in Bipolar Disorder
    Jungwon Cha, Amit Anand · 2021 · Cambridge University Press eBooks
  50. From vulnerability to resilience against depression : the value of daily-life positive emotions
    Nicole Geschwind · 2011 · Research Publications (Maastricht University)
  51. Integrated study on the mRNA expression of the human serotonin transporter
    Meeshanthini Vijayendran · 2012
  52. Genetic gating of human fear, fear learning and extinction : Psychophysiological, brain imaging (fMRI) and clinical studies
    Tina B. Lonsdorf · 2010 · Figshare
  53. Functional Genomics of Serotonin Receptor 2A (HTR2A): Interaction of Polymorphism, Methylation, Expression
    M. Gurbaxani, Elizabeth R. UngerMangalathu, S. Rajeevan · 2010
  54. Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward
    Marlene Oscar‐Berman, Kenneth Blum, Mark S. Gold · 2012
  55. EFFECTS OF SEROTONIN TRANSPORTER PROMOTER POLYMORPHISM (5-HTTLPR) AND NEUROPEPTIDE Y GENE VARIANTS ON ALCOHOL USE IN YOUNG ADULTS
    Mariliis Vaht · 2012
  56. The state of DNA methylation of serotonin transporter (SLC6A4) in peripheral T cells and monocytes is associated with aggression and central 5-HT function; DNA methylation as biomarkers of brain function
    Dongsha Wang · 2012 · eScholarship@McGill (McGill)
  57. Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12–16 October 2014
    Monica Aas, Gabriëlla A.M. Blokland, Samuel J. R. A. Chawner, Shing Wan Choi, Jose Estrada, Annika Forsingdal, Maximilian Uwe Friedrich, Suhas Ganesham, Lynsey S. Hall, Denise Haslinger et al. · 2015 · Psychiatric Genetics
  58. DNA Methylation and Neurology
    Michel Neidhart · 2015 · Elsevier eBooks
  59. A Contextual-Genetics Approach to Adolescent Drug Use and Sexual Risk Behavior
    Gene H. Brody, Steven R. H. Beach, Robert A. Philibert · 2016 · Springer eBooks
  60. Prenatal influences on foetal growth and children's cognition behaviour : Epidemiological and epigenetic studies
    Nina H. Grootendorst van-Mil · 2016
  61. エピジェネティクス機構から精神神経疾患の病態を探る 1.セロトニントランスポーターのDNAメチル化と精神疾患
    緒方 優, 天平 池亀, 美紀 文東, 笠井 清登, 岩本 和也 · 2015 · 日本生物学的精神医学会誌 = Japanese journal of biological psychiatry
  62. Impulse Control Behavior in Movement Disorders: Focus on Restless Leg Syndrome
    Salvatore Galati · 2017 · Springer eBooks
  63. Implications of Epigenetics in Developmental Care of Preterm Infants in the NICU: Preterm Behavioral Epigenetics
    Rosario Montirosso, Livio Provenzi · 2017 · Springer eBooks
  64. Epigenetic and expression-based modifications of depression-relevant genes as peripheral biomarkers for treatment-resistant depression and major depressive disorder
    John R. Pfeiffer · 2017 · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
  65. Mediation and Moderation of Intergenerational Epigenetic Effects of Trauma
    Stefanie R. Pilkay · 2017
  66. Epigenetik der Depression
    Christian Montag, Markus Kiefer, Simon Sanwald · 2018 · Nervenheilkunde
  67. Psychosomatic Medicine and Consultation-Liaison Psychiatry in the United States
    Hoyle Leigh · 2019 · Springer eBooks
  68. Substance Dependence: Overview of the Environmental, Genetic, Epigenetic, and Imaging Studies
    Ranjan Gupta, Arundhati Sharma · 2019 · Springer eBooks
  69. Imaging Genetic and Epigenetic Markers in Mood Disorders
    Sara Poletti, Elena A. Mazza, Benedetta Vai, Francesco Benedetti · 2021 · Cambridge University Press eBooks
  70. Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders
    Poornima Kumar, Yueyi Jiang, Alexis Estelle Whitton · 2021 · Cambridge University Press eBooks
  71. Resting-State Functional Connectivity in Unipolar Depression
    Ziqi Chen, Qiyong Gong · 2021 · Cambridge University Press eBooks
  72. Brain Imaging Methods in Mood Disorders
    Sudhakar Selvaraj, Paolo Brambilla, Jair C. Soares · 2021 · Cambridge University Press eBooks
  73. Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders
    Brent Michael Kious, Perry Franklin Renshaw · 2021 · Cambridge University Press eBooks
  74. Neuroimaging Brain Inflammation in Mood Disorders
    Jeffrey H. Meyer · 2021 · Cambridge University Press eBooks
  75. Functional Near-Infrared Spectroscopy Studies in Mood Disorders
    Koji Matsuo, Toshio Matsubara · 2021 · Cambridge University Press eBooks
  76. Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus
    Danilo Arnone · 2021 · Cambridge University Press eBooks
  77. Neuroimaging Biomarkers in Pediatric Mood Disorders
    Melissa Packer West, Whitney J. Tang, Manpreet K. Singh · 2021 · Cambridge University Press eBooks
  78. fMRI Neurofeedback as Treatment for Depression
    Léon Skottnik, David E.J. Linden · 2021 · Cambridge University Press eBooks
  79. Neuroanatomical Findings in Bipolar Disorder
    Giulia Tronchin, Colm McDonald · 2021 · Cambridge University Press eBooks
  80. Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders
    Estêvão Scotti-Muzzi, Maria Concepción García Otaduy, Márcio Gerhardt Soeiro‐de‐Souza, Rodrigo Machado‐Vieira · 2021 · Cambridge University Press eBooks
  81. Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder
    Sameer Jauhar · 2021 · Cambridge University Press eBooks
  82. Magnetoencephalography Studies in Mood Disorders
    Allison Carol Nugent · 2021 · Cambridge University Press eBooks
  83. Index
    Sudhakar Selvaraj, Paolo Brambilla, Jair C. Soares · 2021 · Cambridge University Press eBooks
  84. Preface
    Sudhakar Selvaraj, Paolo Brambilla, Jair C. Soares · 2021 · Cambridge University Press eBooks
  85. Serotonin Transporter Gene
    Anett Mueller‐Alcazar, Turhan Canli · 2020 · Springer eBooks
  86. Serotonin Transporter Gene
    Anett Mueller‐Alcazar, Turhan Canli · 2013 · Springer eBooks
  87. Adoption Studies
    William R. Yates · 2011 · Encyclopedia of Life Sciences
  88. Genomic markers and psychological health outcomes of drinking behaviours in veterans
    Madeliene Turner · 2022 · Queensland University of Technology
  89. A Relevant Role for Dopamine Transporter Gene in Highly Sensitive Persons under Stressful Conditions: Focus on Genetic and Epigenetic Regulation
    Claudio D’Addario, Fabio Bellia, Alessandro Piccinini, Eugenia Annunzi, Loreta Cannito, Francesca Lionetti, Bernardo Maria Dell’Osso, Walter Adriani, Enrico Dainese, Alberto Di Domenico et al. · 2024 · Research Square
  90. The role of serotonergic activity in impulsive aggression and illegal behavior
    Orlova Nv, G. N. Suvorov · 2025 · Medical alphabet
  91. Genetic and Epigenetic Factors Influencing Methamphetamine Addiction and Aggressive Behavior among Iraqi Adult men
    Haider K. Hussein, Yolanda Loarce, A. Barbaro · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  92. Exploring the Association Between Serotonin Transporter Promoter Region Methylation Levels and Depressive Symptoms: A Systematic Review and Multi-level Meta-Analysis
    Miriam Ringleb, Florian Javelle · 2023 · OSF Preprints (OSF Preprints)
  93. Additional file 1 of Methylation of the serotonin reuptake transporter gene and non-motor symptoms in dystonia patients
    Elze R. Timmers, Torsten Plösch, Marenka Smit, Ingrid H. Hof, Verkaik-Schakel, Rikst Nynke, Marina A.J. Tijssen, Tom J. de Koning, Klary E. Niezen‐Koning · 2024 · Figshare
  94. Genetic and epigenetic regulation of SLC6A4 shapes vulnerability to cognitive decline and depressive tendency in later life
    Yutaro Yanagida, Yutaka Nakachi, Naoto Kajitani, Satoshi Kikkawa, Tempei Ikegame, Shinsuke Koike, Norihide Maikusa, Naohiro Okada, Izumi Naka, Jun Ohashi et al. · 2026 · medRxiv
  95. Approche intégrative des facteurs biologiques et psychologiques associés au pronostic des troubles de l'humeur
    Julia-Lou Consoloni · 2017 · theses.fr (ABES)
  96. What Can We Change and How?
    Franklin Sunzeri · 2026 · Springer eBooks
  97. Correlation of non-suicidal self-injury with SLC6A4 promoter DNA methylation in children and adolescents with bipolar depression
    Alimire Alimujiang, Xiaoqin Shen, ChengJi Wang, Shaohong Zou · 2026 · Frontiers in Psychiatry
  98. Epigenetics, Changing Organizational Contexts, Personality Traits, Stress Regulation and Burnout: An Integrative Multi-Adaptive Biological-Mental-Social Network Analysis
    Debby Bouma, Jan Treur A, Sophie C. F. Hendrikse · 2026 · Studies in systems, decision and control
  99. Epigenetics of generalized internet use disorder including data on overuse of social media: a closer look at the SLC6A4, NR3C1 and OXT genes
    Christian Montag, Markus Kiefer, Bernhard J. Connemann, Thomas Kammer, Simon Sanwald · 2026 · BMC Psychiatry
  100. Epigenetic mechanisms in brain aging and their role in cognitive decline and mental health disorders
    Carlene Chinn, Marcelo Wood · 2026 · Handbook of clinical neurology