The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Family, twin, and adoption studies of bipolar disorder
Abstract
Family, twin, and adoption studies have been essential in defining the genetic epidemiology of bipolar disorder over the past several decades. Family studies have documented that first‐degree relatives of affected individuals have an excess risk of the disorder, while twin studies (and to a lesser extent, adoption studies) suggest that genes are largely responsible for this familial aggregation. We review these studies, including the magnitude of familial risk and heritability estimates, efforts to identify familial subtypes of bipolar disorder, and the implications of family/genetic data for validating nosologic boundaries. Taken together, these studies indicate that bipolar disorder is phenotypically and genetically complex. © 2003 Wiley‐Liss, Inc.
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Citations
Cites
Cross-national epidemiology of major depression and bipolar disorder
Weissman, M. M. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540040037030 · Cited by 2,302
Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia
Badner, J. A., & Gershon, E. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001012 · Cited by 811
A Twin Study of Genetic Relationships Between Psychotic Symptoms
Cardno, A. G., Rijsdijk, F. V., Sham, P. C., Murray, R. M., & McGuffin, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.539 · Cited by 460
Is Response to Prophylactic Lithium a Familial Trait?
Grof, P., Duffy, A., Cavazzoni, P., Grof, E., Garnham, J., MacDougall, M., O'Donovan, C., & Alda, M. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1013 · Cited by 438 · cited 2×
“[1994, 1997] have observed familial clustering of lithium responsiveness and report segregation analyses consistent with single major gene transmission [Grof et al., 2002].”
ResultTwin Studies of Psychiatric Illness: Current Status and Future Directions
Kendler, K. S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820230075007 · Cited by 214
Cited by
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263
A mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120
Self-citationRevisiting the Stress Concept: Implications for Affective Disorders
McEwen, B. S., & Akil, H. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0733-19.2019 · Cited by 686
“Though heritable to various extents (ranging from 35% for MDD to 60% for bipolar disorder; Smoller and Finn, 2003; Geschwind and Flint, 2015), the nature of the vulnerability to these disorders relates to how the individual responds to the environment (Akil et al., 2018).”
BackgroundCommon genetic variants, acting additively, are a major source of risk for autism
Klei, L., Sanders, S. J., Murtha, M. T., Hus, V., Lowe, J. K., Willsey, A. J., Moreno-De-Luca, D., Yu, T. W., Fombonne, E., Geschwind, D., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-9 · Cited by 418
Metadata
- Authors
- Smoller, J. W., & Finn, C. T.
- Venue
- American Journal of Medical Genetics Part C: Seminars in Medical Genetics
- Publisher
- Wiley
- Published
- 2003-08-08
- Volume
- 123C
- Issue
- 1
- Pages
- 48-58
- ISSN
- 1552-4868 (ISSN-L)
- 1552-4876
- OpenAlex
- W2133752646
- Cited by
- 714
- References
- 5
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smoller, J. W., & Finn, C. T. (2003). Family, twin, and adoption studies of bipolar disorder. American Journal of Medical Genetics Part C: Seminars in Medical Genetics. https://doi.org/10.1002/ajmg.c.20013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
