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Cited by 10Antioxidant Activity and Oxidative StressRetinoids in leukemia and cellular processesPrimate Behavior and Ecology

The DOI matches its Crossref record.

Great apes show highly selective plasma carotenoids and have physiologically high plasma retinyl esters compared to humans

García, Ada L., Raila, Jens, Koebnick, Corinna, Eulenberger, Klaus, Schweigert, Florian J.·2006·American Journal of Physical Anthropology
DOI 10.1002/ajpa.20428
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Abstract

Great apes are the closest living relatives of humans. Physiological similarities between great apes and humans provide clues to identify which biological features in humans are primitive or derived from great apes. Vitamin A (VA) and carotenoid metabolism have been only partially studied in great apes, and comparisons between great apes and humans are not available. We aimed to investigate VA and carotenoid intake and plasma concentrations in great apes living in captivity, and to compare them to healthy humans. Dietary intakes of humans (n = 20) and, among the great apes, chimpanzees (n = 15) and orangutans (n = 5) were calculated. Plasma retinol (ROH), retinol-binding protein (RBP), retinyl esters, and major carotenoids were analyzed. The great ape diet was higher in VA than in humans, due to high intake of provitamin A carotenoids. Plasma ROH concentrations in great apes were similar to those in humans, but retinyl esters were higher in great apes than in humans. Differences in plasma carotenoid concentrations were observed between great apes and humans. Lutein was the main carotenoid in great apes, while beta-carotene was the main carotenoid for humans. RBP concentrations did not differ between great apes and humans. The molar ratio of ROH to RBP was close to 1.0 in both great apes and humans. In conclusion, great apes show homeostatic ROH regulation, with high but physiological retinyl esters circulating in plasma. Furthermore, great apes show great selectivity in their plasmatic carotenoid concentration, which is not explained by dietary intake.

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  • In orangutans and chimpanzees plasma REs constitute up to 20% of total retinoids, whereas only 5% in humans.

    “In orangutans and chimpanzees plasma REs constitute up to 20% of total retinoids, whereas only 5% in humans [125].”

    From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [125]

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Research works printed but not linked: 45

  1. Adamson, 1995, Cancer Res, 55, 482
  2. Basabose, 2002, Am J Primatol, 58, 1, 10.1002/ajp.10049 · DOI
  3. Britten, 2002, Proc Natl Acad Sci USA, 99, 13633, 10.1073/pnas.172510699 · DOI · Paper page
  4. Burri, 1993, Am J Vet Res, 54, 1213, 10.2460/ajvr.1993.54.08.1213 · DOI
  5. Cousins, 1976, Acta Zool Pathol Antverp, 66, 91
  6. Crissey, 1999, Zoo Biol, 18, 551, 10.1002/(SICI)1098-2361(1999)18:6<551::AID-ZOO9>3.0.CO;2-S · DOI
  7. Czeczuga, 1982, Folia Histochem Cytochem, 20, 63
  8. Dimitrov, 1988, Am J Clin Nutr, 48, 298, 10.1093/ajcn/48.2.298 · DOI
  9. Doran, 2002, Am J Primatol, 58, 91, 10.1002/ajp.10053 · DOI
  10. Eckhoff, 1991, Toxicol Appl Pharmacol, 111, 116, 10.1016/0041-008X(91)90140-A · DOI
  11. Federal Institute for Health Protection of Consumers and Veterinary Medicine. 1999. The German food code and nutrient data base (BLS II.3): conception, structure and documentation of the data base. Berlin: B Publications. p 45.
  12. Gagneux, 2001, Mol Phylogenet Evol, 18, 2, 10.1006/mpev.2000.0799 · DOI
  13. Gagneux, 2001, Am J Phys Anthropol, 115, 99, 10.1002/ajpa.1061 · DOI
  14. Ghebremeskel, 1988, Comp Biochem Physiol [B], 89, 279, 10.1016/0300-9629(88)91093-6 · DOI
  15. Goodman, 1982, J Am Acad Dermatol, 6, 583, 10.1016/S0190-9622(82)70065-9 · DOI
  16. Gordon, 1982, Crit Rev Food Sci Nutr, 18, 59, 10.1080/10408398209527357 · DOI
  17. Hendrickx, 2000, Reprod Toxicol, 14, 311, 10.1016/S0890-6238(00)00091-5 · DOI
  18. Holden, 1999, J Food Comp Anal, 12, 169, 10.1006/jfca.1999.0827 · DOI
  19. King, 1978, Br J Nutr, 40, 55, 10.1079/BJN19780095 · DOI
  20. Koebnick, 2005, Eur J Clin Nutr, 59, 989, 10.1038/sj.ejcn.1602200 · DOI
  21. Krinsky, 1990, J Nutr, 120, 81, 10.1093/jn/120.1.81 · DOI
  22. Malenkey, 1991, Am J Primatol, 31, 1
  23. McGuire, 1989, J Med Primatol, 18, 155, 10.1111/j.1600-0684.1989.tb00214.x · DOI
  24. Milton, 2003, Comp Biochem Physiol [A], 136, 47, 10.1016/S1095-6433(03)00084-9 · DOI
  25. Neuringer, 2004, Invest Ophthalmol Vis Sci, 45, 3234, 10.1167/iovs.02-1243 · DOI
  26. Olson, 1994, Nutr Rev, 52, 67, 10.1111/j.1753-4887.1994.tb01389.x · DOI
  27. Penniston, 2001, J Nutr, 131, 2904, 10.1093/jn/131.11.2904 · DOI
  28. Penniston, 2003, J Nutr, 133, 4202, 10.1093/jn/133.12.4202 · DOI
  29. Raila, 2000, Vet Res, 31, 541, 10.1051/vetres:2000138 · DOI
  30. Raila, 2002, J Nutr, 132, 1787, 10.1093/jn/132.6.1787S · DOI · Paper page
  31. Rogers, 1993, Comp Biochem Physiol [A], 106, 749, 10.1016/0300-9629(93)90392-H · DOI
  32. Rogers, 2004, Am J Primatol, 64, 173, 10.1002/ajp.20071 · DOI
  33. Ross, 2001, Curr Opin Gastroenterol, 17, 184, 10.1097/00001574-200103000-00015 · DOI
  34. Schweigert, 2000, Int J Vitam Nutr Res, 70, 84, 10.1024/0300-9831.70.3.84 · DOI
  35. Schweigert, 2003, Hum Reprod, 18, 1259, 10.1093/humrep/deg249 · DOI
  36. Slifka, 1999, J Nutr, 129, 380, 10.1093/jn/129.2.380 · DOI
  37. Smith, 1976, N Engl J Med, 294, 805, 10.1056/NEJM197604082941503 · DOI
  38. Snodderly, 1990, J Nutr, 120, 1663, 10.1093/jn/120.12.1663 · DOI
  39. Snodderly, 1997, J Nutr, 127, 122, 10.1093/jn/127.1.122 · DOI
  40. Tanumihardjo, 2002, Int J Vitam Nutr Res, 72, 40, 10.1024/0300-9831.72.1.40 · DOI
  41. Tyssandier, 2002, Am J Clin Nutr, 75, 526, 10.1093/ajcn/75.3.526 · DOI
  42. US Institute of Medicine Food and Nutrition Board, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. 2001. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. A report of the Panel on Micronutrients, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Washington, DC: Food and Nutrition Board, Institute of Medicine, National Academy Press.
  43. Vahlquist, 1972, Biochemistry, 11, 4526, 10.1021/bi00774a015 · DOI
  44. Vitamin A Tracer Task Force. 2004. Appropriate uses of vitamin A tracer (stable isotope) methodology. Washington, DC: ILSI Human Nutrition Institute.
  45. Wolever, 1997, Adv Exp Med Biol, 427, 35, 10.1007/978-1-4615-5967-2_4 · DOI

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Metadata

Authors
García, A. L., Raila, J., Koebnick, C., Eulenberger, K., & Schweigert, F. J.
Affiliations
  • University of Potsdam (DE)
  • German Institute of Human Nutrition (DE)
Corresponding author
García, Ada L.
ORCID
Venue
American Journal of Physical Anthropology
Publisher
Wiley
Published
2006
Volume
131
Issue
2
Pages
236-242
ISSN
  • 0002-9483 (ISSN-L)
  • 1096-8644
DOI
10.1002/ajpa.20428
OpenAlex
W2152543924
Cited by
10
References
0
Citations by year
2025: 1 · 2020: 1 · 2018: 1 · 2016: 2 · 2015: 1
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3530 d)
Locations
  • American Journal of Physical Anthropology (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
  • publish.UP (University of Potsdam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
Keywords
great apes, vitamin A metabolism, carotenoids, retinyl esters, retinol, retinol-binding protein, lutein, beta-carotene, dietary intake, chimpanzees, orangutans, primate evolution, vitamin A homeostasis, captivity
MeSH terms
Lycopene, Animals, Carotenoids, Diet, Eating, Female, Humans, Male, Retinol-Binding Proteins, Species Specificity, Vitamin A, Lutein, Hominidae, Xanthophylls, Retinol-Binding Proteins, Plasma, Zeaxanthins

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