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Cited by 44Sinusitis and nasal conditionsCystic Fibrosis Research AdvancesOlfactory and Sensory Function Studies

Cognitive dysfunction associated with pain and quality of life in chronic rhinosinusitis

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Tarasidis, George S., DeConde, Adam S., Mace, Jess C., Ashby, Shaelene, Smith, Timothy L., Orlandi, Richard R., Alt, Jeremiah A.·2015·International Forum of Allergy & Rhinology
DOI 10.1002/alr.21578PMC PMC4688255
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Abstract

Background: Cognitive dysfunction and its relationship to both pain and disease‐specific quality of life (QOL) in chronic rhinosinusitis (CRS) have not been investigated previously. We sought to analyze the correlations of pain and disease‐specific QOL with cognitive function in CRS. Methods: Adults with CRS were prospectively enrolled in a cross‐sectional study. Participants’ cognitive function was assessed using the Cognitive Failures Questionnaire. Pain was characterized using the Short‐Form McGill Pain Questionnaire (SF‐MPQ) and the Brief Pain Inventory Short Form. Disease‐specific QOL was ascertained using the Rhinosinusitis Disability Index (RSDI) and 22‐item Sinonasal Outcome Test (SNOT‐22). Disease severity was assessed using nasal endoscopy and computed tomography. Bivariate correlations of pain and cognitive dysfunction, disease‐specific QOL, and clinical measures of disease severity were ascertained. Results: In patients with CRS (n = 70) there was a significant correlation between cognitive dysfunction and pain severity scores (Spearman's correlation [R s] = 0.321, p < 0.01). A similar correlation was identified with pain interference (R s = 0.317, p < 0.01) and cognitive dysfunction scores. This is mirrored by a significant correlation between another measure of pain severity, the SF‐MPQ and cognitive dysfunction (R s = 0.498, p < 0.01). In patients with CRS there was a significant correlation between disease‐specific QOL scores and cognitive function scores as measured by the SNOT‐22 (R s = 0.395, p < 0.01) and the RSDI (R s = 0.528, p < 0.01). Conclusion: In patients with CRS, increasing pain and worse QOL are associated with cognitive dysfunction. Possible mechanisms for this cognitive dysfunction include differential neural activation secondary to chronic pain and/or the sequela of a chronic inflammatory state.

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  • Nasal symptoms do not seem to correlate well with the cognitive impairment observed for chronic rhinosinusitis.

    “On the other hand, nasal symptoms do not seem to correlate well with the cognitive impairment observed for CRS [115].”

    From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [115]

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Authors
Tarasidis, G. S., DeConde, A. S., Mace, J. C., Ashby, S., Smith, T. L., Orlandi, R. R., & Alt, J. A.
Affiliations
  • University of Utah (US)
  • University of California San Diego (US)
  • Oregon Health & Science University (US)
Corresponding author
Alt, Jeremiah A.
ORCID
Venue
International Forum of Allergy & Rhinology
Publisher
Wiley
Published
2015-06-22
Volume
5
Issue
11
Pages
1004-1009
ISSN
  • 2042-6976 (ISSN-L)
  • 2042-6984
DOI
10.1002/alr.21578
PMC
PMC4688255
OpenAlex
W1603170271
Cited by
44
References
1
Citations by year
2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2
FWCI
3.30
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Forum of Allergy & Rhinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (National Institute on Deafness and Other Communication Disorders [NIDCD] (R01 DC005805)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
chronic rhinosinusitis, cognitive impairment, pain, quality of life, disease-specific quality of life, pain interference, cognitive failure, chronic pain, chronic inflammation, nasal endoscopy, computed tomography
MeSH terms
Adult, Aged, Chronic Disease, Cognition Disorders, Female, Humans, Male, Middle Aged, Pain, Prospective Studies, Quality of Life, Surveys and Questionnaires, Rhinitis, Severity of Illness Index, Sinusitis

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