Cancer and risk of Alzheimer's disease: Small association in a nationwide cohort study
Open accessAbstract
Introduction: Small observational studies with short‐term follow‐up suggest that cancer patients are at reduced risk of Alzheimer's disease (AD) compared to the general population. Methods: A nationwide cohort study using Danish population‐based health registries (1980‐2013) with cancer patients (n = 949,309) to identify incident diagnoses of AD. We computed absolute reductions in risk attributed to cancer and standardized incidence rate ratios (SIRs) accounting for survival time, comparing the observed to expected number of AD cases. Results: During up to 34 years of follow‐up of cancer survivors, the attributable risk reduction was 1.3 per 10,000 person‐years, SIR = 0.94 (95% confidence interval 0.92‐0.96). SIRs were similar after stratification by sex, age, and cancer stage, and approached that of the general population for those surviving >10 years. Discussion: Inverse associations between cancer and AD were small and diminished over time. Incidence rates in cancer survivors approached those of the general population, suggesting limited association between cancer and AD risk.
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Sensitivity analysis in observational research: Introducing the E-value
VanderWeele, T. J., & Ding, P. (2017) · Annals of Internal Medicine · doi:10.7326/m16-2607 · Cited by 6,350 · see citing works
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992 · see citing works
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- Authors
- Ording, A. G., Horváth‐Puhó, E., Veres, K., Glymour, M. M., Rørth, M., Sørensen, H. T., & Henderson, V. W.
- Affiliations
- Aarhus University Hospital (DK)
- Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark
- University of California, San Francisco (US)
- Corresponding author
- Ording, Anne G.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2020-05-20
- Volume
- 16
- Issue
- 7
- Pages
- 953-964
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC7351601
- OpenAlex
- W3028040166
- Cited by
- 47
- References
- 3
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 9 · 2022: 9 · 2021: 4 · 2020: 3
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Lundbeckfonden (R248‐2017‐521)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, cancer survivors
- MeSH terms
- Cancer Survivors, Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Child, Child, Preschool, Denmark, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Neoplasms, Registries, Risk, Incidence, Survival Rate, Young Adult
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