The Ca 2+ hypothesis for Alzheimer's disease (AD) conceives Ca 2+ dyshomeostasis as a common mechanism of AD; the cause of Ca 2+ dysregulation, however, is obscure. Meanwhile, hyperactivities of N‐Methyl‐D‐aspartate receptors (NMDARs), the primary mediator of Ca 2+ influx, are reported in AD. Glu…