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Cited by 16Dementia and Cognitive Impairment ResearchPhysical Activity and HealthAlzheimer's disease research and treatments

Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias

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Park, Song‐Yi, Setiawan, Veronica Wendy, White, Lon R., Wu, Anna H., Cheng, Iona, Haiman, Christopher A., Wilkens, Lynne R., Le Marchand, Loїc +1 more·2023·Alzheimer's & Dementia
DOI 10.1002/alz.12677PMC PMC9810117
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Abstract

Introduction: We investigated whether the protective association of physical activity with risk of Alzheimer's disease and related dementias (ADRD) has genetic or behavioral variations. Methods: In the Multiethnic Cohort, we analyzed moderate or vigorous physical activity (MVPA) reported at ages 45 to 75 among 88,047 participants in relation to 13,039 incident diagnoses of late‐onset ADRD identified in Medicare claims (1999 to 2014), by five racial and ethnic groups, hours sitting, and in a subset (16%), apolipoprotein E (APOE) genotype. Results: MVPA was inversely associated with ADRD (hazard ratio for ≥14 vs <2.5 hours/week: 0.83, 95% confidence interval [CI]: 0.76 to 0.90 in men; 0.88, 5% CI: 0.81 to 0.95 in women). The association was inverse in all racial and ethnic groups except Black participants (P‐heterogeneity = 0.52), but stronger in individuals with lower levels of sitting duration or those who do not carry the APOE e4 risk allele. Discussion: The different effects of physical activity by sitting duration and APOE genotype warrant further research.

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  • Some studies have suggested an interaction between APOE genotype and modifiable risk factors, whereby carrying the APOEε4 allele would multiply the increased Alzheimer disease risk associated with the risk factor alone or counteract the reduced Alzheimer disease risk conferred by a protective factor, such as education attainment or physical exercise.

    “Indeed, some studies have suggested an interaction between APOE genotype and several of these modifiable risk factors, whereby carrying the APOEε4 allele would multiply the increased AD risk associated with the risk factor alone (for example, cardiovascular risk factors30) or counteract the reduced AD risk conferred by a protective factor, such as education attainment31 or physical exercise32.”

    From Multifaceted roles of APOE in Alzheimer disease (2024) · cites this paper as [32]

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Cited by

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Authors
Park, S., Setiawan, V. W., White, L. R., Wu, A. H., Cheng, I., Haiman, C. A., Wilkens, L. R., Le Marchand, L., & Lim, U.
Affiliations
  • Cancer Center of Hawaii (US)
  • University of Southern California (US)
  • University of Hawaiʻi at Mānoa (US)
  • University of California, San Francisco (US)
  • Cancer Epidemiology Program University of Hawaii Cancer Center University of Hawaii Honolulu Hawaii USA
Corresponding author
Park, Song‐Yi
ORCID
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2022-04-27
Volume
19
Issue
2
Pages
507-517
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
DOI
10.1002/alz.12677
PMC
PMC9810117
OpenAlex
W4225011353
Cited by
16
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 6
FWCI
2.28
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (U01 CA164973, U01 CA164973 08S1)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
physical activity, Alzheimer's disease and related dementias
MeSH terms
Aged, Alzheimer Disease, Apolipoproteins E, Ethnicity, Female, Medicare, Humans, Male, Middle Aged, Risk Factors, United States, Exercise

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