Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions

Hou, Yujun; Chu, Xixia; Park, Jae‐Hyeon; Zhu, Qing; Hussain, Mansoor; Li, Zhiquan; Madsen, Helena Borland; Yang, Beimeng; Wei, Yong; Wang, Yue; Fang, Evandro F.; Croteau, Deborah L.; Bohr, Vilhelm A.

doi:10.1002/alz.13847

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions

BACKGROUND: Compromised autophagy, including impaired mitophagy and lysosomal function, plays pivotal roles in Alzheimer's disease (AD). Urolithin A (UA) is a gut microbial metabolite of ellagic acid that stimulates mitophagy. The effects of UA's long‐term treatment of AD and mechanisms of action…