The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside: Animal Model of Axonal GBS
Abstract
Some humans develop the axonal form of Guillain-Barré syndrome after receiving bovine brain ganglioside. On sensitization with the ganglioside mixture, all of a group of rabbits injected developed high anti-GM1 IgG antibody titers, flaccid limb weakness of acute onset, and a monophasic illness course. Pathological findings for the peripheral nerves showed predominant Wallerian-like degeneration, with neither lymphocytic infiltration nor demyelination. IgG was deposited on the axons of the anterior roots, and GM1 was proved to be present on the axons of peripheral nerves. Sensitization with purified GM1 also induced axonal neuropathy, indicating that GM1 was the immunogen in the mixture. A model of human axonal Guillain-Barré syndrome has been established that uses inoculation with a bovine brain ganglioside mixture or isolated GM1. This model may help to clarify the molecular pathogenesis of the syndrome and to develop new treatments for it.
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Cites
Electrophysiological classification of guillain‐barré syndrome: Clinical associations and outcome
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Acute motor axonal neuropathy: A frequent cause of acute flaccid paralysis in China
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AN ACUTE AXONAL FORM OF GUILLAIN-BARRÉE POLYNEUROPATHY
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Acute motor axonal neuropathy: An antibody‐mediated attack on axolemma
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Self-citationPathology of the motor‐sensory axonal Guillain‐Barré syndrome
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Anti-GD1a antibody is associated with axonal but not demyelinating forms of Guillain-Barr� syndrome
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Cited by
Schnaar, R. L., Gerardy-Schahn, R., & Hildebrandt, H. (2014) · Physiological Reviews · doi:10.1152/physrev.00033.2013 · Cited by 745
Peripheral neuropathies and anti-glycolipid antibodies
Willison, H. J. (2002) · Brain · doi:10.1093/brain/awf272 · Cited by 710
Kaida, K., Ariga, T., & Yu, R. K. (2009) · Glycobiology · doi:10.1093/glycob/cwp027 · Cited by 155
Guillain-Barré syndrome and anti-ganglioside antibodies: A clinician-scientist’s journey
YUKI, N. (2012) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.88.299 · Cited by 109
Self-citationSialylated intravenous immunoglobulin suppress anti-ganglioside antibody mediated nerve injury
Zhang, G., Massaad, C. A., Gao, T., Pillai, L., Bogdanova, N., Ghauri, S., & Sheikh, K. A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.020 · Cited by 38
Metadata
- Authors
- Yuki, N., Yamada, M., Koga, M., Odaka, M., Susuki, K., Tagawa, Y., Ueda, S., Kasama, T., Ohnishi, A., Hayashi, S., Takahashi, H., Kamijo, M., & Hirata, K.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-04-02
- Volume
- 49
- Issue
- 6
- Pages
- 712-720
- ISSN
- 0364-5134 (ISSN-L)
- OpenAlex
- W2121636757
- Cited by
- 323
- References
- 29
- FWCI
- 14.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuki, N., Yamada, M., Koga, M., Odaka, M., Susuki, K., Tagawa, Y., Ueda, S., Kasama, T., Ohnishi, A., Hayashi, S., Takahashi, H., Kamijo, M., & Hirata, K. (2001). Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside: Animal Model of Axonal GBS. Annals of Neurology. https://doi.org/10.1002/ana.1012
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