The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Thalamic neurodegeneration in multiple sclerosis
Abstract
Multiple sclerosis is still regarded primarily as a disease of the white matter. However, recent evidence suggests that there may be significant involvement of gray matter. Here, we have used magnetic resonance imaging and magnetic resonance spectroscopy in vivo and histopathology postmortem to estimate thalamic neuronal loss in patients with multiple sclerosis. Our results show that neuronal loss in multiple sclerosis can be substantial (30–35% reduction). We conclude that a neurodegenerative pathology may make a major contribution to the genesis of symptoms in multiple sclerosis.
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Cites
Estimation of nuclear population from microtome sections
Abercrombie, M. (1946) · The Anatomical Record · doi:10.1002/ar.1090940210 · Cited by 4,363
Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403 · cited 2×
“GM also may be a common focus for inflammatory damage.(6) The aim of our study was to assess the extent of neuronal loss in thalamic GM of patients with MS using imaging methods and then to validate the measurements with parallel histopathological studies performed on (different) postmortem material.”
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Cited by
The relation between inflammation and neurodegeneration in multiple sclerosis brains
Frischer, J. M., Bramow, S., Dal-Bianco, A., Lucchinetti, C. F., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., & Lassmann, H. (2009) · Brain · doi:10.1093/brain/awp070 · Cited by 1,450
Progressive multiple sclerosis: pathology and pathogenesis
Lassmann, H., van Horssen, J., & Mahad, D. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.168 · Cited by 1,033
Lassmann, H. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028936 · Cited by 937
Association between pathological and MRI findings in multiple sclerosis
Filippi, M., Rocca, M. A., Barkhof, F., Brück, W., Chen, J. T., Comi, G., DeLuca, G., De Stefano, N., Erickson, B. J., Evangelou, N., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70003-0 · Cited by 486
Neocortical neuronal, synaptic, and glial loss in multiple sclerosis
Wegner, C., Esiri, M. M., Chance, S. A., Palace, J., & Matthews, P. M. (2006) · Neurology · doi:10.1212/01.wnl.0000237551.26858.39 · Cited by 441
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Metadata
- Authors
- Cifelli, A., Arridge, M., Jezzard, P., Esiri, M. M., Palace, J., & Matthews, P. M.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2002-08-25
- Volume
- 52
- Issue
- 5
- Pages
- 650-653
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1998299241
- Cited by
- 490
- References
- 2
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cifelli, A., Arridge, M., Jezzard, P., Esiri, M. M., Palace, J., & Matthews, P. M. (2002). Thalamic neurodegeneration in multiple sclerosis. Annals of Neurology. https://doi.org/10.1002/ana.10326
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