Reappraisal of the human vestibular cortex by cortical electrical stimulation study
Abstract
The cortical areas with vestibular input in humans were assessed by electrical stimulation in 260 patients with partial epilepsy who had undergone stereotactic intracerebral electroencephalogram recordings before surgery. Vestibular symptoms were electrically induced on 44 anatomical sites in 28 patients. The patients experienced illusions of rotation (yaw plane: 18, pitch plane: 6, roll plane: 6), translations (n = 6), or indefinable feelings of body motion (n = 8). Almost all vestibular sites were located in the cortex (41/44): in the temporal (n = 19), parietal (n = 14), frontal (n = 5), occipital (n = 2), and insular (n = 1) lobes. Among these sites, we identified a lateral cortical temporoparietal area we called the temporo-peri-Sylvian vestibular cortex (TPSVC), from which vestibular symptoms, and above all rotatory sensations, were particularly easily elicited (24/41 cortical sites, 58.5%). This area extended above and below the Sylvian fissure, mainly inside Brodmann areas 40, 21, and 22. It included the parietal operculum (9/24 TPSVC sites) which was particularly sensitive for eliciting pitch plane illusions, and the mid and posterior part of the first and second temporal gyri (15/24 TPSVC sites) which preferentially caused yaw plane illusions. We suggest that the TPSVC could be homologous with the monkey's parietoinsular vestibular cortex.
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A wide variety of other effects have been reported from ACC stimulation, including digestive sensations, vestibular hallucinations, anxiety and physical pain, and fear in the pregenual ACC.
“A wide variety of other effects have been reported, including digestive sensations (Mulak et al., 2008), vestibular hallucinations (Kahane et al., 2003), anxiety and physical pain (Kahane et al., 2003;Mulak et al., 2008), and in the pregenual ACC, fear (Fox et al., 2020).”
From Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain (2021) · cites this paper as Kahane et al., 2003
Human vestibular cortex is located in close proximity to the TPJ.
“the location of human vestibular cortex in close proximity to the TPJ”
From Multisensory mechanisms in temporo-parietal cortex support self-location and first-person perspective (2011) · cites this paper as Kahane et al., 2003
Clinical data suggest that remapping of self-location and first-person perspective from the physical body position to an elevated and distanced position and first-person perspective in extrapersonal space at the TPJ is based on a double disintegration of bodily signals, including disintegration between visual and vestibular signals.
“These clinical data suggest that remapping of self-location and first-person perspective from the physical body position to an elevated and distanced position and firstperson perspective in extrapersonal space at the TPJ is based on a double disintegration of bodily signals, including disintegration between visual and vestibular signals.”
From Multisensory mechanisms in temporo-parietal cortex support self-location and first-person perspective (2011) · cites this paper as Kahane et al., 2003
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References 51 · Cited by 278
- Authors
- Kahane, P., Hoffmann, D., Minotti, L., & Berthoz, A.
- Affiliations
- Centre Hospitalier Universitaire de Grenoble (FR)
- Collège de France (FR)
- Corresponding author
- Kahane, Philippe
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2003-10-02
- Volume
- 54
- Issue
- 5
- Pages
- 615-624
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2074186648
- Cited by
- 278
- References
- 51
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 15 · 2023: 14 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 14 · 2018: 9 · 2017: 16 · 2016: 15 · 2015: 24 · 2014: 19 · 2013: 14 · 2012: 9
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- vestibular cortex, cortical electrical stimulation, vestibular illusions, parietal operculum, temporal lobe, parietal lobe, epilepsy surgery
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cerebral Cortex, Child, Child, Preschool, Electric Stimulation, Electrodes, Implanted, Electroencephalography, Epilepsies, Partial, Female, Humans, Male, Middle Aged, Vestibule, Labyrinth
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