Noradrenergic modulation of space exploration in visual neglect
Abstract
Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive effects of guanfacine were associated with extended ability to maintain attention on task. The results suggest that neuropharmacological targeting of intact frontal areas might be one way to enhance cognitive function after damage to posterior brain regions in selected individuals.
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Guanfacine enhances cognition and attention in patients with impairments due to encephalitis or strokes, as long as PFC remains sufficiently intact.
“Guanfacine has also been shown to enhance cognition and attention in patients with impairments due to encephalitis (Singh-Curry et al., 2011), or strokes, as long as the PFC itself remains sufficiently intact to provide a therapeutic target for drug actions (Malhotra, Parton, Greenwood, & Husain, 2006).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Malhotra, Parton, Greenwood, & Husain, 2006
Cites
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · see citing works
A cortical network for directed attention and unilateral neglect
Mesulam, M. ‐. (1981) · Annals of Neurology · doi:10.1002/ana.410100402 · Cited by 2,498 · see citing works
Localization of a human system for sustained attention by positron emission tomography
Pardo, J. V., Fox, P. T., & Raichle, M. E. (1991) · Nature · doi:10.1038/349061a0 · Cited by 1,284 · see citing works
Paus, T., Zatorre, R. J., Hofle, N., Caramanos, Z., Gotman, J., Petrides, M., & Evans, A. C. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.3.392 · Cited by 514 · see citing works
Frontal lesions and sustained attention
Wilkins, A. J., Shallice, T., & McCarthy, R. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90024-8 · Cited by 450 · see citing works
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Parr, T., & Friston, K. J. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0376 · Cited by 252 · see citing works
Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107327 · Cited by 75 · see citing works
Hains, A. B., Yabe, Y., & Arnsten, A. F. T. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.01.001 · Cited by 70 · see citing works
- Authors
- Malhotra, P. A., Parton, A. D., Greenwood, R., & Husain, M.
- Affiliations
- Charing Cross Hospital (GB)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-12-22
- Volume
- 59
- Issue
- 1
- Pages
- 186-190
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2158160583
- Cited by
- 114
- References
- 5
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 13 · 2012: 3
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (061140)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- visual neglect, stroke, noradrenergic modulation, guanfacine, space exploration, dorsolateral prefrontal cortex, attention, right hemisphere damage
- MeSH terms
- Adrenergic alpha-Agonists, Animals, Attention, Humans, Neuropsychological Tests, Norepinephrine, Perceptual Disorders, Space Perception, Visual Perception, Guanfacine, Stroke
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