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Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis
Abstract
Objective: We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis. Methods: Prospective study of patients with initial LETM who were tested for the presence of NMO‐IgG. Results: Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004). Interpretation: LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO‐IgG are at high risk for relapse. Ann Neurol 2006
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Metadata
- Authors
- Weinshenker, B. G., Wingerchuk, D. M., Vukusic, S., Linbo, L., Pittock, S. J., Lucchinetti, C. F., & Lennon, V. A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2006-02-17
- Volume
- 59
- Issue
- 3
- Pages
- 566-569
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2006660240
- Cited by
- 588
- References
- 0
- FWCI
- 28.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weinshenker, B. G., Wingerchuk, D. M., Vukusic, S., Linbo, L., Pittock, S. J., Lucchinetti, C. F., & Lennon, V. A. (2006). Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Annals of Neurology. https://doi.org/10.1002/ana.20770
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