Is microglial apoptosis an early pathogenic change in cerebral X‐linked adrenoleukodystrophy?

Objective Mutations in the X‐linked adrenoleukodystrophy (X‐ALD) protein cause accumulation of unbranched saturated very‐long‐chain fatty acids, particularly in brain and adrenal cortex. In humans, the genetic defect causes progressive inflammatory demyelination in the brain, where very‐long‐chai…