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Primary infection with the Epstein‐Barr virus and risk of multiple sclerosis
Open accessAbstract
To determine whether multiple sclerosis (MS) risk increases following primary infection with the Epstein‐Barr virus (EBV), we conducted a nested case‐control study including 305 individuals who developed MS and 610 matched controls selected among the >8 million active‐duty military personnel whose serum has been stored in the Department of Defense Serum Repository. Time of EBV infection was determined by measuring antibody titers in serial serum samples collected before MS onset among cases, and on matched dates among controls. Ten (3.3%) cases and 32 (5.2%) controls were initially EBV negative. All of the 10 EBV‐negative cases became EBV positive before MS onset; in contrast, only 35.7% (n = 10) of the 28 controls with follow‐up samples seroconverted (exact p value = 0.0008). We conclude that MS risk is extremely low among individuals not infected with EBV, but it increases sharply in the same individuals following EBV infection. ANN NEUROL 2010;67:824–830
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Cited by
Bjornevik, K., Cortese, M., Healy, B. C., Kuhle, J., Mina, M. J., Leng, Y., Elledge, S. J., Niebuhr, D. W., Scher, A. I., Munger, K. L., et al. (2022) · Science · doi:10.1126/science.abj8222 · Cited by 2,049
Self-citationAbrahamyan, S., Eberspächer, B., Hoshi, M.-M., Aly, L., Luessi, F., Groppa, S., Klotz, L., Meuth, S. G., Schroeder, C., Grüter, T., et al. (2020) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-322941 · Cited by 119
Aloisi, F., Serafini, B., Magliozzi, R., Howell, O. W., & Reynolds, R. (2010) · Brain · doi:10.1093/brain/awq223 · Cited by 73
Multiple sclerosis in Japan appears to be a milder disease compared to the UK
Piccolo, L., Kumar, G., Nakashima, I., Misu, T., Kong, Y., Wakerley, B., Ryan, S., Cavey, A., Fujihara, K., & Palace, J. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7637-3 · Cited by 57
Allanach, J. R., Fettig, N. M., Hardman, B. K., Rosen, A. R., Fan, V., Chung, C., Goldberg, E. J., Morse, Z. J., Shanina, I., Vorobeychik, G., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu5110 · Cited by 14
Metadata
- Authors
- Levin, L. I., Munger, K. L., O'Reilly, E. J., Falk, K. I., & Ascherio, A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-05-25
- Volume
- 67
- Issue
- 6
- Pages
- 824-830
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2112982280
- Cited by
- 404
- References
- 0
- FWCI
- 18.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Levin, L. I., Munger, K. L., O'Reilly, E. J., Falk, K. I., & Ascherio, A. (2010). Primary infection with the Epstein‐Barr virus and risk of multiple sclerosis. Annals of Neurology. https://doi.org/10.1002/ana.21978
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