The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Visceral fat is associated with lower brain volume in healthy middle‐aged adults
Open accessAbstract
Objective: Midlife obesity has been associated with an increased risk of dementia. The underlying mechanisms are poorly understood. Our aim was to examine the cross‐sectional association of body mass index (BMI), waist circumference (WC), waist‐to‐hip ratio (WHR), and computed tomography (CT)‐based measurements of subcutaneous (SAT) and visceral (VAT) adipose tissue with various magnetic resonance imaging (MRI) markers of brain aging in middle‐aged community adults. Methods: Participants from the Framingham Offspring cohort were eligible if in addition to having measurements of BMI, WC, WHR, SAT, and VAT, they had undergone a volumetric brain MRI scan with measurements of total brain volume (TCBV), temporal horn volume (THV), white matter hyperintensity volume (WMHV), and MRI‐defined brain infarcts (BI). All analyses were adjusted for age, sex, and time interval between abdominal CT and brain MRI. Results: In a sample of 733 community participants (mean age, 60 years; 53% women), we observed an inverse association of BMI (estimate by standard deviation unit ± standard error = −0.27 ± 0.12; p = 0.02), WC (−0.30 ± 0.12; p = 0.01), WHR (−0.37 ± 0.12; p = 0.02), SAT (−0.23 ± 0.11; p = 0.04), and VAT (−0.36 ± 0.12; p = 0.002) with TCBV, independent of vascular risk factors. The association between VAT and TCBV was the strongest and most robust, and was also independent of BMI (−0.35 ± 0.15; p = 0.02) and insulin resistance (−0.32 ± 0.13; p = 0.01). When adjusting for C‐reactive protein levels, the associations were attenuated (−0.17 ± 0.13; p = 0.17 for VAT). No consistently significant association was observed between the anthropometric or CT‐based abdominal fat measurements and THV, WMHV, or BI. Interpretation: In middle‐aged community participants, we observed a significant inverse association of anthropometric and CT‐based measurements of abdominal, especially visceral, fat with total brain volume. ANN NEUROL 2010
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Self-citationSilent Brain Infarcts and the Risk of Dementia and Cognitive Decline
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Self-citationBrain metabolic dysfunction at the core of Alzheimer's disease
de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 461
Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II study
Singh‐Manoux, A., Dugravot, A., Shipley, M., Brunner, E. J., Elbaz, A., Sabia, S., & Kivimaki, M. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.06.2637 · Cited by 401
Michailidis, M., Moraitou, D., Tata, D. A., Kalinderi, K., Papamitsou, T., & Papaliagkas, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052687 · Cited by 330
The Prefrontal Cortex and Obesity: A Health Neuroscience Perspective
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Metadata
- Authors
- Debette, S., Beiser, A., Hoffmann, U., DeCarli, C., O'Donnell, C. J., Massaro, J. M., Au, R., Himali, J. J., Wolf, P. A., Fox, C. S., & Seshadri, S.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-08
- Volume
- 68
- Issue
- 2
- Pages
- 136-144
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1980508061
- Cited by
- 253
- References
- 59
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Debette, S., Beiser, A., Hoffmann, U., DeCarli, C., O'Donnell, C. J., Massaro, J. M., Au, R., Himali, J. J., Wolf, P. A., Fox, C. S., & Seshadri, S. (2010). Visceral fat is associated with lower brain volume in healthy middle‐aged adults. Annals of Neurology. https://doi.org/10.1002/ana.22062
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