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Cited by 610Epilepsy research and treatmentSuicide and Self-Harm StudiesMental Health Treatment and Access

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Epilepsy, suicidality, and psychiatric disorders: A bidirectional association

Hesdorffer, Dale C., Ishihara, Lianna, Mynepalli, Lakshmi, Webb, David J., Weil, John, Hauser, W. Allen·2012·Annals of Neurology
DOI 10.1002/ana.23601
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Abstract

Objective: A study was undertaken to determine whether psychiatric disorders associated with suicide are more common in incident epilepsy than in matched controls without epilepsy, before and after epilepsy diagnosis. Methods: A matched, longitudinal cohort study was conducted in the UK General Practice Research Database. A total of 3,773 cases diagnosed with epilepsy between the ages of 10 and 60 years were compared to 14,025 controls matched by year of birth, sex, general practice, and years of medical records before the index date. We examined first diagnosis of psychosis, depression, anxiety, and suicidality in each of the 3 years before and after the index date and annual prevalence of suicide. Referent diagnoses were eczema and acute surgery. The incidence rate ratio (IRR) was calculated for each year in the study period; the prevalence ratio (PR) was calculated for suicidality. Results: The IRR of psychosis, depression, and anxiety was significantly increased for all years before epilepsy diagnosis (IRR, 1.5–15.7) and after diagnosis (IRR, 2.2–10.9) and for suicidality before epilepsy diagnosis (IRR, 3.1–4.5) and 1 year after diagnosis (IRR, 5.3). The PR was increased for suicide attempt before epilepsy onset (PR, 2.6–5.2) and after onset (PR, 2.4–5.6). Eczema and acute surgery were both associated with epilepsy in the first and third year after diagnosis. Interpretation: Epilepsy is associated with an increased onset of psychiatric disorders and suicide before and after epilepsy diagnosis. These relations suggest common underlying pathophysiological mechanisms that both lower seizure threshold and increase risk for psychiatric disorders and suicide. ANN NEUROL 2012

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Metadata

Authors
Hesdorffer, D. C., Ishihara, L., Mynepalli, L., Webb, D. J., Weil, J., & Hauser, W. A.
Affiliations
  • Columbia University (US)
  • GlaxoSmithKline (United Kingdom) (GB)
  • GlaxoSmithKline (India) (IN)
Corresponding author
Hesdorffer, Dale C.
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
2012-08
Volume
72
Issue
2
Pages
184-191
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.23601
OpenAlex
W1973942337
Cited by
610
References
46
Citations by year
2026: 21 · 2025: 58 · 2024: 58 · 2023: 41 · 2022: 44 · 2021: 45 · 2020: 63 · 2019: 38 · 2018: 33 · 2017: 41 · 2016: 49 · 2015: 40 · 2014: 42 · 2013: 30 · 2012: 6
FWCI
26.87
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
GlaxoSmithKline
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords
epilepsy, suicidality, suicide attempts, psychiatric comorbidity, psychosis, depression, anxiety, bidirectional relationship, seizure threshold
MeSH terms
Adolescent, Adult, Mental Disorders, Child, Epilepsy, Female, United Kingdom, Humans, Male, Middle Aged, Suicide, Cohort Studies, Comorbidity, Incidence, Confidence Intervals, Case-Control Studies, Young Adult

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