Aquaporin 4‐specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter

Varrin‐Doyer, Michel; Spencer, Collin M.; Schulze‐Topphoff, Ulf; Nelson, Patricia A.; Stroud, Robert M.; C. Cree, Bruce A.; Zamvil, Scott S.

doi:10.1002/ana.23651

Aquaporin 4‐specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter

Objective: Aquaporin 4 (AQP4)‐specific autoantibodies in neuromyelitis optica (NMO) are immunoglobulin (Ig)G1, a T cell‐dependent Ig subclass, indicating that AQP4‐specific T cells participate in NMO pathogenesis. Our goal was to identify and characterize AQP4‐specific T cells in NMO patients and…