Losartan prevents acquired epilepsy via TGF‐β signaling suppression

Bar‐Klein, Guy, Cacheaux, Luisa P., Kamintsky, Lyn, Prager, Ofer, Weissberg, Itai, Schoknecht, Karl, Cheng, Paul, Kim, Soo Young, Wood, Lydia, Heinemann, Uwe, Kaufer, Daniela, Friedman, Alon·2014·Annals of Neurology

DOI 10.1002/ana.24147

Cited by (270)

Items 101–200 of 270

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Ulrich Fabien Prodjinotho, Vitka Gres, Fiona D. R. Henkel, Matthew Lacorcia, Ramona Dandl, Martin Haslbeck, Veronika Schmidt, Andrea Sylvia Winkler, Chummy Sikalizyo Sikasunge, Per‐Johan Jakobsson et al. · 2022 · EMBO Reports
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Erez Hanael, Ronel Veksler, Alon Friedman, Guy Bar‐Klein, Vladimir V. Senatorov, Daniela Kaufer, Lilach Konstantin, Maria Elkin, Orit Chai, Dana Peery et al. · 2019 · Epilepsia
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Pavel Klein, Ivana Tyrlíková · 2017 · Epilepsy & Behavior
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Selected Molecular Targets for Antiepileptogenesis
Marek J. Pawlik, Barbara Miziak, Aleksandra Walczak, Agnieszka Konarzewska, Magdalena Chrościńska–Krawczyk, Jan Albrecht, Stanisław Jerzy Czuczwar · 2021 · International Journal of Molecular Sciences
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Lanqing Zhao, Jinwei Li, Reetta K. Kälviäinen, Jukka Jolkkonen, Chuansheng Zhao · 2021 · Pharmacology & Therapeutics
The GR‐ANXA1 pathway is a pathological player and a candidate target in epilepsy
Emma Zub, Geoffrey Canet, Rita Garbelli, Marine Blaquière, L Rossini, Chiara Pastori, Madeeha H. Sheikh, Chris P.M. Reutelingsperger, Wendy Klément, Frédéric de Bock et al. · 2019 · The FASEB Journal
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Tatiana N. Zamay, Замай Галина Сергеевна, Natalia Alekseevna Shnayder, Д. В. Дмитренко, Замай Сергей Сергеевич, Victoria Yushchenko, Olga S. Kolovskaya, Vanessa Susevski, Maxim V. Berezovski, Anna S. Kichkailo · 2019 · Molecular Therapy — Nucleic Acids
Epilepsy and Alterations of the Blood–Brain Barrier: Cause or Consequence of Epileptic Seizures or Both?
Wolfgang Löscher · 2020 · Handbook of experimental pharmacology
Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model
Taisuke Kato, Ri-ichiroh Manabe, Hironaka Igarashi, Fuyuki Kametani, Sachiko Hirokawa, Yumi Sekine, Natsumi Fujita, Satoshi Saito, Yusuke Kawashima, Yuya Hatano et al. · 2021 · Journal of Clinical Investigation
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Samantha P. Martin, Beth A. Leeman-Markowski · 2024 · Frontiers in Neurology
The angiotensin II type I receptor antagonist losartan retards amygdala kindling-induced epileptogenesis
Toshiki Nozaki, Hiroyuki Ura, Ichiro Takumi, Shiro Kobayashi, Eiichi Maru, Akio Morita · 2018 · Brain Research
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Losartan reduces the immediate and sustained increases in muscle sympathetic nerve activity after hyperacute intermittent hypoxia
Noah Jouett, Gilbert Moralez, Peter Bernard Raven, Michael L. Smith · 2017 · Journal of Applied Physiology
Evidence Implicating Blood-Brain Barrier Impairment in the Pathogenesis of Acquired Epilepsy following Acute Organophosphate Intoxication
Pedro N. Bernardino, Audrey Luo, Peter M. Andrew, Chelsea M. Crowe, Marco I. González, Angie Gelli, Pamela J. Lein · 2023 · Journal of Pharmacology and Experimental Therapeutics
Antagonism of Macrophage Migration Inhibitory Factory (MIF) after Traumatic Brain Injury Ameliorates Astrocytosis and Peripheral Lymphocyte Activation and Expansion
M. Karen Newell‐Rogers, Susannah K. Rogers, Richard P. Tobin, Sanjib Mukherjee, Lee A. Shapiro · 2020 · International Journal of Molecular Sciences
TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands
Serge Nataf, Marine Guillen, Laurent Pays · 2019 · International Journal of Molecular Sciences
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy
Yang Su, Meng Tang, Minjin Wang · 2023 · Aging and Disease
sec‐Butyl‐propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon‐induced status epilepticus in rats
Guy Bar‐Klein, Evyatar Swissa, Lyna Kamintsky, Tawfeeq Shekh‐Ahmad, Rotem Saar‐Ashkenazy, Yechiel Hubary, Shai Shrot, Liran Stetlander, Arik Eisenkraft, Alon Friedman et al. · 2014 · Epilepsia
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Astrocytes: Stars of the Sacred Disease
Devin K. Binder · 2018 · Epiliepsy currents/Epilepsy currents
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Jinkun Han, Ying Wang, Penghu Wei, Di Lu, Yongzhi Shan · 2024 · Frontiers in Neurology
The Role of Blood–Brain Barrier Disruption in Epilepsy: Mechanisms and Consequences
Elena M. Suleymanova, Anna A. Karan · 2025 · Neurology International
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Matthias J. Koepp, Eugen Trinka, Wolfgang Löscher, Pavel Klein · 2024 · Current Opinion in Neurology
2014 Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression
Aristea S. Galanopoulou, Michael Wong, Devin K. Binder, Adam L. Hartman, Elizabeth M. Powell, Avtar Roopra, Richard J. Staba, Annamaria Vezzani, Brandy E. Fureman, Raymond J Dingledine · 2016 · Epiliepsy currents/Epilepsy currents
Role of neural barriers in the pathogenesis and outcome of Streptococcus pneumoniae meningitis
Ofer Prager, Alon Friedman, Yaffa Mizrachi Nebenzahl · 2017 · Experimental and Therapeutic Medicine
P2Y4/TSP-1/TGF-β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid
Yurong Zhang, Wei Zhu, Haiying Yu, Jie Yu, Mengdi Zhang, Xiaohong Pan, Xue Juan Gao, Qiaoyun Wang, Hongliu Sun · 2019 · Brain Research Bulletin
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Cong Li, Huijing Chen, Qijia Tan, Caijun Xie, Wengang Zhan, Aruna Sharma, Hari Shanker Sharma, Zhiqiang Zhang · 2020 · Progress in brain research
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis
Yan Wei Hu, Buliang Meng, Saige Yin, Meifeng Yang, Yilin Li, Naixin Liu, Shanshan Li, Yixiang Liu, Dandan Sun, Siyu Wang et al. · 2022 · Journal of Neuroinflammation
Molecular biomarkers in drug-resistant epilepsy: Facts & possibilities
Aparna Banerjee Dixit, Manjari Tripathi, Poodipedi Sarat Chandra, Jyotirmoy Banerjee · 2015 · International Journal of Surgery
Losartan suppresses the kainate-induced changes of angiotensin AT1 receptor expression in a model of comorbid hypertension and epilepsy
Dimitrinka Atanasova, Jana Dimitrova Tchekalarova, Natasha M. Ivanova, Zlatina Nenchovska, Ekaterina Pavlova, Nina N. Atanassova, Nikolai Lazarov · 2017 · Life Sciences
Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus
Yurong Zhang, Mengdi Zhang, Wei Zhu, Xiaohong Pan, Qiaoyun Wang, Xue Juan Gao, Chaoyun Wang, Xiuli Zhang, Yuxia Liu, Shucui Li et al. · 2019 · Neuroscience Bulletin
The Role of Sartans in the Treatment of Stroke and Subarachnoid Hemorrhage: A Narrative Review of Preclinical and Clinical Studies
Stefan Wanderer, Basil Erwin Grüter, Fabio Strange, Sivani Sivanrupan, Stefano Di Santo, Hans Rudolf Widmer, Javier Fandino, Serge Marbacher, Lukas Andereggen · 2020 · Brain Sciences
Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review
Peng Chen, Fuchao Chen, Benhong Zhou · 2022 · Journal of Integrative Neuroscience
Transcriptome Profiling of the Hippocampal Seizure Network Implicates a Role for Wnt Signaling during Epileptogenesis in a Mouse Model of Temporal Lobe Epilepsy
Muriel D. Mardones, Kunal Gupta · 2022 · International Journal of Molecular Sciences
Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury
Shubham Misra, Erum I. Khan, TuKiet T. Lam, Rajarshi Mazumder, Kapil Gururangan, L. Brian Hickman, Vaibhav Goswami, Melissa Christine Funaro, Ece Eldem, Lauren Hachmann Sansing et al. · 2023 · Neurology
Dynamic miRNA changes during the process of epileptogenesis in an infantile and adult-onset model
Petra Bencúrová, Jiří Baloun, Jakub Hynšt, Jan Oppelt, Hana Kubová, Šárka Pospı́šilová, Milan Brázdil · 2021 · Scientific Reports
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Dimitrios A. Kazis, Simela Chatzikonstantinou, Alin Stelian Ciobica, Fatima Zahra Kamal, Vasile Burlui, Gabriela Călin, Ioannis Asterios Mavroudis · 2024 · Biomedicines
Loss of protection by antiepileptic drugs in lipopolysaccharide-primed pilocarpine-induced status epilepticus is mediated via inflammatory signalling.
Preeti Vyas, R. Tulsawani, D. Vohora · 2020 · Neuroscience
Neuroinflammation impact in epileptogenesis and new treatment strategy
Amal M. Mahfoz, Naiyer Shahzad · 2019 · Behavioural Pharmacology
Losartan enhances cognitive and structural neuroplasticity impairments in spontaneously hypertensive rats
Heriberto Coatl-Cuaya, Hiram Tendilla‐Beltrán, Luis Manuel de Jesús-Vásquez, Linda Garcés‐Ramírez, María de Jesús Gómez‐Villalobos, Gonzalo Flores · 2021 · Journal of Chemical Neuroanatomy
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Dipan C. Patel, Karen S. Wilcox, Cameron S. Metcalf · 2017 · Epiliepsy currents/Epilepsy currents
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Weihua Yu, Yan Zou, Yingshi Du, Jing Luo, Man Zhang, Wenxiu Yang, Xuefeng Wang, Yang Lü · 2014 · Neurochemical Research
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Iman Imtiyaz Ahmed Juvale, Ahmad Tarmizi Che Has · 2020 · European Journal of Neuroscience
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Shu Liu, Yang Xu, Fei Chen, Zhiyou Cai · 2023 · Journal of Biomedical Research
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