The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Natural history of pure autonomic failure: A United States prospective cohort
Open accessAbstract
Objective: To define the clinical features and biomarkers that predict which patients with pure autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple system atrophy. Methods: One hundred patients who presented with pure autonomic failure were recruited at 5 medical centers in the United States. Seventy‐four patients agreed to be followed prospectively. Patients underwent clinical evaluations including neurological rating scales, sleep questionnaires, smell test, and sympathetic and parasympathetic cardiovascular autonomic function tests. Results: At enrollment, patients were 68 ± 12 years old (median ± interquartile range) and had had autonomic failure for 5 ± 7 years. Within 4 years of follow‐up, 25 of 74 subjects (34%) developed dementia with Lewy bodies (n = 13), Parkinson disease (n = 6), or multiple system atrophy (n = 6). The presence of probable rapid eye movement (REM) sleep behavior disorder was strongly associated with the development of a manifest central nervous system (CNS) synucleinopathy (odds ratio = 7.1). Patients who phenoconverted to multiple system atrophy had younger age at onset of autonomic failure, severe bladder/bowel dysfunction, preserved olfaction, and a cardiac chronotropic response upon tilt > 10 beats per minute. Those who phenoconverted to Parkinson disease or dementia with Lewy bodies had decreased olfaction, a lesser chronotropic response to tilt, and a longer duration of illness. The small group of patients retaining the pure autonomic failure phenotype had very low plasma norepinephrine levels, slow resting heart rate, no REM sleep behavior disorder, and preserved smell. Interpretation: Patients presenting with pure autonomic failure are at high risk of phenoconverting to a manifest CNS synucleinopathy. Specific clinical features predict future diagnosis. Ann Neurol 2017;81:287–297
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Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
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Second consensus statement on the diagnosis of multiple system atrophy
Gilman, S., Wenning, G. K., Low, P. A., Brooks, D. J., Mathias, C. J., Trojanowski, J. Q., Wood, N. W., Colosimo, C., Dürr, A., Fowler, C. J., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000324625.00404.15 · Cited by 3,140
Self-citationFreeman, R., Wieling, W., Axelrod, F. B., Benditt, D. G., Benarroch, E., Biaggioni, I., Cheshire, W. P., Chelimsky, T., Cortelli, P., Gibbons, C. H., et al. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-011-0119-5 · Cited by 1,697 · cited 1×
“Autonomic function testing confirmed that all patients met criteria for autonomic failure.(21) Resting supine BP was 152/84mmHg (IQR 5 15/10), and the prevalence of supine hypertension was 47%.”
BackgroundSelf-citationFreeman, R., Wieling, W., Axelrod, F. B., Benditt, D. G., Benarroch, E., Biaggioni, I., Cheshire, W. P., Chelimsky, T., Cortelli, P., Gibbons, C. H., et al. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.02.004 · Cited by 1,243
Self-citationα-Synuclein strains cause distinct synucleinopathies after local and systemic administration
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Blood pressure recovery from Valsalva maneuver in patients with autonomic failure
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Self-citationIs cardiac function impaired in premotor Parkinson's disease? A retrospective cohort study
Palma, J., Carmona‐Abellan, M., Barriobero, N., Trevino-Peinado, C., Garcia‐Lopez, M., Fernandez‐Jarne, E., & Luquin, M. R. (2013) · Movement Disorders · doi:10.1002/mds.25431 · Cited by 77
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The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
Wenning, G. K., Stankovic, I., Vignatelli, L., Fanciulli, A., Calandra‐Buonaura, G., Seppi, K., Palma, J., Meissner, W. G., Krismer, F., Berg, D., et al. (2022) · Movement Disorders · doi:10.1002/mds.29005 · Cited by 833
Self-citationRossi, M., Candelise, N., Baiardi, S., Capellari, S., Giannini, G., Orrù, C. D., Antelmi, E., Mammana, A., Hughson, A. G., Calandra-Buonaura, G., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02160-8 · Cited by 451
Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis
Borghammer, P., & Van Den Berge, N. (2019) · Journal of Parkinson’s Disease · doi:10.3233/jpd-191721 · Cited by 419
Prodromal Parkinson disease subtypes — key to understanding heterogeneity
Berg, D., Borghammer, P., Fereshtehnejad, S.-M., Heinzel, S., Horsager, J., Schaeffer, E., & Postuma, R. B. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00486-9 · Cited by 409
Chen, Z., Li, G., & Liu, J. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104700 · Cited by 363
Metadata
- Authors
- Kaufmann, H., Norcliffe‐Kaufmann, L., Palma, J., Biaggioni, I., Low, P. A., Singer, W., Goldstein, D. S., Peltier, A. C., Shibao, C. A., Gibbons, C. H., Freeman, R., Robertson, D., & on behalf of the Autonomic Disorders Consortium
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2017-02
- Volume
- 81
- Issue
- 2
- Pages
- 287-297
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2617170837
- Cited by
- 298
- References
- 8
- FWCI
- 19.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaufmann, H., Norcliffe‐Kaufmann, L., Palma, J., Biaggioni, I., Low, P. A., Singer, W., Goldstein, D. S., Peltier, A. C., Shibao, C. A., Gibbons, C. H., Freeman, R., Robertson, D., & on behalf of the Autonomic Disorders Consortium. (2017). Natural history of pure autonomic failure: A United States prospective cohort. Annals of Neurology. https://doi.org/10.1002/ana.24877
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