Cerebrospinal fluid vasopressin and symptom severity in children with autism
Open accessAbstract
Autism is a brain disorder characterized by social impairments. Progress in understanding autism has been hindered by difficulty in obtaining brain-relevant tissues (eg, cerebrospinal fluid [CSF]) by which to identify markers of disease and targets for treatment. Here, we overcome this barrier by providing evidence that mean CSF concentration of the "social" neuropeptide arginine vasopressin (AVP) is lower in children with autism versus controls. CSF AVP concentration also significantly differentiates individual cases from controls and is associated with greater social symptom severity in children with autism. These findings indicate that AVP may be a promising CSF marker of autism's social deficits. Ann Neurol 2018;84:611-615.
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Investigations in pediatric autism spectrum disorder and control samples also found decreased cerebrospinal fluid vasopressin.
“This led to investigations in pediatric ASD and control samples that also found decreased cerebrospinal fluid AVP (167, 168).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [168]
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References 21 · Cited by 59
- Authors
- Oztan, O., Garner, J. P., Partap, S., Sherr, E. H., Hardan, A. Y., Farmer, C., Thurm, A., Swedo, S. E., & Parker, K. J.
- Affiliations
- Stanford University (US)
- Stanford Medicine (US)
- University of California, San Francisco (US)
- National Institute of Mental Health (US)
- Corresponding author
- Parker, Karen J.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2018-09-26
- Volume
- 84
- Issue
- 4
- Pages
- 611-615
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC6719782
- OpenAlex
- W2889035274
- Cited by
- 59
- References
- 21
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 11 · 2020: 5 · 2019: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (ZIA MH002914, NCT00298246)
- Weston Havens Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, vasopressin, cerebrospinal fluid biomarkers, social dysfunction, children, neuropeptides
- MeSH terms
- Autistic Disorder, Child, Child, Preschool, Female, Humans, Male, Neurophysins, Protein Precursors, Severity of Illness Index, Vasopressins, Biomarkers, Case-Control Studies
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