The DOI matches its Crossref record.
Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents
Abstract
An unusual case of spongiform encephalopathy was transmitted directly from a human to rats and mice. After serial passages, incubation periods were shortened to about six months in rats and four months in mice. Clinical symptoms were similar in rats and mice, including ruffled fur, arched back, bradykinesia, and hind limb paralysis. Pathologically, a spongy state, proliferation of astrocytes, and neuronal changes were observed. Electron microscopic observation of the parietal cortex of rats and mice disclosed many membrane‐bound vacuoles in the neuropil, predominantly in dendrites. In the pons of mice, intramyelinic vacuoles and accumulation of extracellular fluid were prominent. The clinicopathological symptoms of the affected animals resembled those in other experimental spongiform encephalopathies, especially scrapie.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
Hsiao, K., Baker, H. F., Crow, T. J., Poulter, M., Owen, F., Terwilliger, J. D., Westaway, D., Ott, J., & Prusiner, S. B. (1989) · Nature · doi:10.1038/338342a0 · Cited by 849
Genetic prion disease: the EUROCJD experience
Kovács, G. G., Puopolo, M., Ladogana, A., Pocchiari, M., Budka, H., van Duijn, C., Collins, S. J., Boyd, A., Giulivi, A., Coulthart, M., et al. (2005) · Human Genetics · doi:10.1007/s00439-005-0020-1 · Cited by 450
Bellingham, S. A., Coleman, B. M., & Hill, A. F. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks832 · Cited by 440
Packaging of prions into exosomes is associated with a novel pathway of PrP processing
Vella, L., Sharples, R., Lawson, V., Masters, C., Cappai, R., & Hill, A. (2007) · The Journal of Pathology · doi:10.1002/path.2145 · Cited by 425
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins
Butler, D. A., Scott, M. R., Bockman, J. M., Borchelt, D. R., Taraboulos, A., Hsiao, K. K., Kingsbury, D. T., & Prusiner, S. B. (1988) · Journal of Virology · doi:10.1128/jvi.62.5.1558-1564.1988 · Cited by 366
Metadata
- Authors
- Tateishi, J., Ohta, M., Koga, M., Sato, Y., & Kuroiwa, Y.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1979-06
- Volume
- 5
- Issue
- 6
- Pages
- 581-584
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2051391548
- Cited by
- 192
- References
- 0
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents. https://app.cochat.ai/papers/10.1002/ana.410050616
- The paper
- Tateishi, J., Ohta, M., Koga, M., Sato, Y., & Kuroiwa, Y. (1979). Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents. Annals of Neurology. https://doi.org/10.1002/ana.410050616
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
