The DOI matches its Crossref record; 58 of the 92 references it cites were found in a registry or an index.
Experimental models of virus-induced demyelination of the central nervous system
Open accessAbstract
One of the arguments in favor of a viral pathogenesis for multiple sclerosis is the existence of several experimental and natural animal models of virus‐induced primary demyelination. This review deals comprehensively with such models. Well‐known examples of demyelinating viral infections in their natural host are JHM, Theiler, visna, and canine distemper encephalomyelitides. Recent reports of experimental murine infections with pathogens such as vesicular stomatitis, Chandipura, herpes simplex, Venezuelan equine encephalomyelitis, and Semliki Forest viruses are also discussed. The thrust of the review is to include viral models suspected of producing primary demyelination on an immunopathological basis.
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“Although previous studies do not indicate VEEV is related to neurodegeneration, VEEV neurological sequelae share progressive characteristics of neurodegenerative disorders including cognitive, motor, or sensory deficits [4,14,15].”
From VEEV TC-83 Triggers Dysregulation of the Tryptophan–Kynurenine Pathway in the Central Nervous System That Correlates with Cognitive Impairment in Tg2576 Mice (2024) · cites this paper as [14]
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Cites
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Cited by
Sorted by citations
Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis
Lucchinetti, C. F., Brück, W., Rodriguez, M., & Lassmann, H. (1996) · Brain Pathology · doi:10.1111/j.1750-3639.1996.tb00854.x · Cited by 733
Osame, M., Matsumoto, M., Usuku, K., Izumo, S., Ijichi, N., Amitani, H., Tara, M., & Igata, A. (1987) · Annals of Neurology · doi:10.1002/ana.410210203 · Cited by 657
Storch, M., Stefferl, A., Brehm, U., Weissert, R., Wallström, E., Kerschensteiner, M., Olsson, T., Linington, C., & Lassmann, H. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00194.x · Cited by 566
“Many attempts have been undertaken to create animal models of chronic inflammatory demyelinating diseases through autoimmunity (23, 36, 40) or virus infection (4, 9, 10, 15, 21, 37).”
BackgroundPain, Analgesia, and Addiction
Weiner, L. P., & Fleming, J. O. (1984) · Neurology · doi:10.1212/wnl.34.6.846 · Cited by 358
Pathogenesis and immunopathology of systemic and nervous canine distemper.
Beineke, A., Puff, C., Seehusen, F., & Baumgärtner, W. (2009) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2008.09.023 · Cited by 338
“Due to similarities distemper represents a useful model to study the pathogenesis of human demyelinating immune mediated diseases including MS (Koestner, 1975; Cook et al., 1978; Dal Canto and Rabinowitz, 1982; Hodge and Wolfson, 1997; Baumgärtner and Alldinger, 2005).”
Metadata
- Authors
- Dal Canto, M. C., & Rabinowitz, S. G.
- Affiliations
- Northwestern University (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1982-02
- Volume
- 11
- Issue
- 2
- Pages
- 109-127
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC7159566
- OpenAlex
- W2025146338
- Cited by
- 173
- References
- 92
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 1 · 2019: 4 · 2017: 1 · 2016: 4 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- demyelination, multiple sclerosis, viral pathogenesis, animal models, JHM virus, Theiler's virus, visna virus, canine distemper virus, vesicular stomatitis virus, Chandipura virus, herpes simplex virus, Venezuelan equine encephalitis virus, Semliki Forest virus, central nervous system demyelination, immunopathology
- MeSH terms
- Animals, Antibodies, Viral, Central Nervous System Diseases, Coronaviridae Infections, Demyelinating Diseases, Disease Models, Animal, Distemper, Distemper Virus, Canine, Dogs, Encephalitis Virus, Venezuelan Equine, Maus Elberfeld virus, Enterovirus Infections, Herpes Simplex, Multiple Sclerosis, Pneumonia, Progressive Interstitial, of Sheep, Rhabdoviridae, Sheep, Virus Diseases, Visna-maedi virus
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