The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Central nervous system excitatory effects of meperidine in cancer patients
Abstract
The analgesic meperidine has been reported to produce signs of central nervous system excitation in human beings. To determine the relationship between signs and symptoms of central nervous system excitation and plasma levels of meperidine and normeperidine, we studied 67 patients receiving meperidine for the relief of postoperative or chronic pain. In 48 patients, excitatory effects ranging from mild nervousness to tremors, twitches, multifocal myoclonus, and seizures were directly correlated with accumulation of normeperidine in plasma. Evidence of compromised renal function occurred in only 14 of the 48 symptomatic patients, suggesting that renal dysfunction may contribute to but is not the sole factor in the accumulation of normeperidine or its relation to adverse neurological signs. In a second study we surveyed mood alterations in 47 patients receiving meperidine and 29 receiving other narcotic analgesics for postoperative pain. The repeated administration of meperidine was associated with adverse alterations in various elements of mood (e.g., apprehension, sadness, restlessness).
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Cites
MuiQuy, B. (1981) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1981.30.5.tm0300051146a · Cited by 966
SZETO, H. H., INTURRISI, C. E., HOUDE, R., SAAL, S., CHEIGH, J., & REIDENBERG, M. M. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-86-6-738 · Cited by 357
Self-citationLasagna, L. (1955) · Journal of the American Medical Association · doi:10.1001/jama.1955.02950290026009 · Cited by 280
Meperidine kinetics in man; Intravenous injection in surgical patients and volunteers
Mather, L. E., Tucker, G. T., Pflug, A. E., LINDOP, M. J., & Wilkerson, C. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt197517121 · Cited by 196
Janowitz, H. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91317-3 · Cited by 178
The effect of cirrhosis on the disposition and elimination of meperidine in man
Klotz, U., McHorse, T. S., Wilkinson, G. R., & Schenker, S. (1974) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1974164667 · Cited by 165
Classification of Opioids on the Basis of Change in Seizure Threshold in Rats
Cowan, A., Geller, E. B., & Adler, M. W. (1979) · Science · doi:10.1126/science.504986 · Cited by 154
Clinical pharmacology of analgesics: 1. A method of assaying analgesic effect
Houde, R. W., Wallenstein, S. L., & Rogers, A. G. (1960) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt196012163 · Cited by 121
Self-citationAnalgesic and Mood Effects of Heroin and Morphine in Cancer Patients with Postoperative Pain
Kaiko, R. F., Wallenstein, S. L., Rogers, A. G., Grabinski, P. Y., & Houde, R. W. (1981) · New England Journal of Medicine · doi:10.1056/nejm198106183042501 · Cited by 110
Self-citationDangerous Potentiation of Pethidine by Iproniazid, and its Treatment
Shee, J. C. (1960) · BMJ · doi:10.1136/bmj.2.5197.507 · Cited by 92
Cited by
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
Gilson, A. M., Ryan, K. M., Joranson, D. E., & Dahl, J. L. (2004) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2004.01.003 · Cited by 340
COMPARISON OF PROPOFOL AND MIDAZOLAM FOR SEDATION IN CRITICALLY ILL PATIENTS
Aitkenhead, A., Willatts, S., Park, G., Collins, C., Ledingham, I., Pepperman, M., David Coates, P., Bodenham, A., Smith, M., & Wallace, P. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90770-8 · Cited by 213
Analgesic Drug Therapy in Cancer Pain: Principles and Practice
Foley, K. M., & Inturrisi, C. E. (1987) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30866-5 · Cited by 103
Self-citation
Metadata
- Authors
- Kaiko, R. F., Foley, K. M., Grabinski, P. Y., Heidrich, G., Rogers, A. G., Inturrisi, C. E., & Reidenberg, M. M.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1983-02
- Volume
- 13
- Issue
- 2
- Pages
- 180-185
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2058598889
- Cited by
- 408
- References
- 13
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Central nervous system excitatory effects of meperidine in cancer patients. https://app.cochat.ai/papers/10.1002/ana.410130213
- The paper
- Kaiko, R. F., Foley, K. M., Grabinski, P. Y., Heidrich, G., Rogers, A. G., Inturrisi, C. E., & Reidenberg, M. M. (1983). Central nervous system excitatory effects of meperidine in cancer patients. Annals of Neurology. https://doi.org/10.1002/ana.410130213
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
