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Baclofen in the treatment of trigeminal neuralgia: Double‐blind study and long‐term follow‐up
Abstract
A double‐blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia. Baclofen significantly decreased the number of painful paroxysms in 7 of the 10 patients. An open trial in another 50 patients with trigeminal neuralgia refractory to or unable to tolerate carbamazepine showed that 37 (74%) were relieved of their attacks by baclofen, either alone (12 patients) or in combination with previously ineffective doses of carbamazepine or phenytoin (25). On long‐term follow‐up of one to five years (mean, 3.0 years), 18 of the 60 patients (30%) continued pain free while receiving baclofen; 10 (17%) went into remission after 3 to 6 months; 13 (22%) became refractory to baclofen after 1 to 18 months; and 2 (3%) elected operation despite a good response to baclofen. The results indicate that baclofen is a useful drug in the treatment of trigeminal neuralgia.
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Cited by
AAN-EFNS guidelines on trigeminal neuralgia management
Cruccu, G., Gronseth, G., Alksne, J., Argoff, C., Brainin, M., Burchiel, K., Nurmikko, T., & Zakrzewska, J. M. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02185.x · Cited by 726
Trigeminal neuralgia—pathophysiology, diagnosis and current treatment
Nurmikko, T. J., & Eldridge, P. R. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.117 · Cited by 417
Combination pharmacotherapy for the treatment of neuropathic pain in adults
Chaparro, L. E., Wiffen, P. J., Moore, R. A., & Gilron, I. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008943.pub2 · Cited by 310
Treatments for spasticity and pain in multiple sclerosis: a systematic review
Beard, S., Hunn, A., & Wight, J. (2003) · Health Technology Assessment · doi:10.3310/hta7400 · Cited by 266
(1988) · doi:10.1001/archneur.1989.00520450030015 · Cited by 173
Metadata
- Authors
- Fromm, G. H., Terrence, C. F., & Chattha, A. S.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1984-03
- Volume
- 15
- Issue
- 3
- Pages
- 240-244
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2025817423
- Cited by
- 368
- References
- 0
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fromm, G. H., Terrence, C. F., & Chattha, A. S. (1984). Baclofen in the treatment of trigeminal neuralgia: Double‐blind study and long‐term follow‐up. Annals of Neurology. https://doi.org/10.1002/ana.410150306
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