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Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases
Abstract
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.
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Citations
Cited by
Protection against Japanese Encephalitis by Inactivated Vaccines
Hoke, C. H., Nisalak, A., Sangawhipa, N., Jatanasen, S., Laorakapongse, T., Innis, B. L., Kotchasenee, S.-O., Gingrich, J. B., Latendresse, J., Fukai, K., et al. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809083191004 · Cited by 417
Self-citationSolomon, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030476 · Cited by 394
Japanese encephalitis — the prospects for new treatments
Turtle, L., & Solomon, T. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2018.30 · Cited by 344
Brainstem Encephalitis (Rhombencephalitis) Due to Listeria monocytogenes: Case Report and Review
Armstrong, R. W., & Fung, P. C. (1993) · Clinical Infectious Diseases · doi:10.1093/clind/16.5.689 · Cited by 306
Japanese encephalitis vaccines
Halstead, S. B., & Jacobson, J. (2008) · Vaccines · doi:10.1016/b978-1-4160-3611-1.50021-0 · Cited by 264
Metadata
- Authors
- Johnson, R. T., Burke, D. S., Elwell, M., Leake, C. J., Nisalak, A., Hoke, C. H., & Lorsomrudee, W.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1985-11
- Volume
- 18
- Issue
- 5
- Pages
- 567-573
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2088407671
- Cited by
- 231
- References
- 0
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases. https://app.cochat.ai/papers/10.1002/ana.410180510
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- Johnson, R. T., Burke, D. S., Elwell, M., Leake, C. J., Nisalak, A., Hoke, C. H., & Lorsomrudee, W. (1985). Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases. Annals of Neurology. https://doi.org/10.1002/ana.410180510
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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