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Inhibition of L‐{18F}fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography
Abstract
The brain uptake of L‐{18 F}fluorodopa was measured by positron emission tomography in a healthy male volunteer both under fasting conditions and during intravenous amino acid loading. A significant reduction of tracer uptake into the brain was demonstrated with amino acid loading. This finding represents the first direct evidence for competition between L‐dopa and other amino acids for uptake across the blood–brain barrier obtained in vivo in a human subject. It underlines the possible importance of interference by dietary amino acids with the therapeutic actions of L‐dopa in Parkinson's disease.
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Citations
Cited by
Levodopa in Parkinson’s Disease: Current Status and Future Developments
Tambasco, N., Romoli, M., & Calabresi, P. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170510143821 · Cited by 282
Members, E. W. E., Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Bennekou, S. H., Leist, M., & Schildknecht, S. (2018) · Archives of Toxicology · doi:10.1007/s00204-017-2133-4 · Cited by 124
Motor and Nonmotor Complications of Levodopa: Phenomenology, Risk Factors, and Imaging Features
Ray Chaudhuri, K., Poewe, W., & Brooks, D. (2018) · Movement Disorders · doi:10.1002/mds.27386 · Cited by 121
Self-citationNutt, J. G., Woodward, W. R., Carter, J. H., & Trotman, T. L. (1989) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.4.481 · Cited by 49
Akashi, T., Noguchi, S., Takahashi, Y., Nishimura, T., & Tomi, M. (2023) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2022.12.028 · Cited by 8
Metadata
- Authors
- Leenders, K. L., Poewe, W. H., Palmer, A. J., Brenton, D. P., & Frackowiak, R. S. J.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1986-08
- Volume
- 20
- Issue
- 2
- Pages
- 258-262
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1995544693
- Cited by
- 172
- References
- 0
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of L‐{18F}fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography. https://app.cochat.ai/papers/10.1002/ana.410200212
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- Leenders, K. L., Poewe, W. H., Palmer, A. J., Brenton, D. P., & Frackowiak, R. S. J. (1986). Inhibition of L‐{18F}fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography. Annals of Neurology. https://doi.org/10.1002/ana.410200212
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
