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Cited by 211Parkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effectsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 13 of the 14 references it cites were found in a registry or an index.

A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease

Fahn, Stanley·1992·Annals of Neurology
DOI 10.1002/ana.410320722
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Abstract

High dosages of a combination of alpha-tocopherol and ascorbate were administered to patients with early Parkinson's disease as an open-labeled trial and pilot study to test the endogenous toxic hypothesis of the etiology of Parkinson's disease. Patients receiving concomitant amantadine and anticholinergics were allowed to participate, but those receiving levodopa or dopamine agonists were not. The study was begun prior to the availability of deprenyl. The primary end point of the trial was progression of the disease until patients needed treatment with levodopa or a dopamine agonist. The time when levodopa became necessary in the treated patients was compared to another group of patients followed elsewhere who did not receive antioxidants. The time when levodopa became necessary was extended by 2.5 years in the group receiving alpha-tocopherol and ascorbate. Results of this pilot study suggest that the progression of Parkinson's disease may be slowed by administration of these antioxidants. Controlled clinical trials using double-blind randomization techniques are required to confirm these results.

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Crossref · 10.1002/ana.410320722

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Research works printed but not linked: 3

  1. Cohen, 1983, Neural Transm, 19, 89
  2. Graham, 1984, Neurotoxicology, 5, 83
  3. Olanow, 1990, Neurology, 40, 32

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Metadata

Authors
Fahn, S.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
Fahn, Stanley
Venue
Annals of Neurology
Publisher
Wiley
Published
1992
Volume
32
Issue
S1
Pages
S128-S132
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.410320722
OpenAlex
W2112404451
Cited by
211
References
14
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 9 · 2013: 4 · 2012: 3
FWCI
14.62
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 8644 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
Parkinson's disease, alpha-tocopherol, vitamin C, antioxidants, disease progression, early-stage Parkinson's disease, amantadine, anticholinergic agents
MeSH terms
Adult, Aged, Ascorbic Acid, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Parkinson Disease, Pilot Projects, Research Design, Vitamin E

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