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FK506‐induced neurotoxicity in liver transplantation
Abstract
We report FK506‐induced neurotoxicity in 14 of 44 consecutive patients following orthoptic liver transplantation. In 10 of these 14 patients, postural hand tremors were found in the first weeks following surgery, transient apraxia of speech in 3, and generalized tonic‐clonic seizures were noted in 2 patients. Other manifestations included nightmares, agitation, and acute delirium. Reduction of the FK506 dose resulted in resolution of symptoms, but in 1 patient mild speech difficulties and in 3 patients a fine tremor remained. Blood and plasma levels of FK506 were similar in patients with and without neurotoxicity. FK506 neurotoxicity in patients with liver transplantation commonly results in transient neurological manifestations. The incidence of neurotoxicity in FK506 is dramatically reduced in maintenance doses of 0.075 mg/kg twice a day.
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Cited by
A Reversible Posterior Leukoencephalopathy Syndrome
Hinchey, J., Chaves, C., Appignani, B., Breen, J., Pao, L., Wang, A., Pessin, M. S., Lamy, C., Mas, J.-L., & Caplan, L. R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602223340803 · Cited by 3,340
Rozkalne, A., Hyman, B. T., & Spires-Jones, T. L. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.11.014 · Cited by 103
Gaber, A. O., Alloway, R. R., Bodziak, K., Kaplan, B., & Bunnapradist, S. (2013) · Transplantation · doi:10.1097/tp.0b013e3182962cc1 · Cited by 100
Metadata
- Authors
- Wijdicks, E. F. M., Wiesner, R. H., Dahlke, L. J., & Krom, R. A. F.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1994-04
- Volume
- 35
- Issue
- 4
- Pages
- 498-501
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2011017461
- Cited by
- 159
- References
- 0
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: FK506‐induced neurotoxicity in liver transplantation. https://app.cochat.ai/papers/10.1002/ana.410350422
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- Wijdicks, E. F. M., Wiesner, R. H., Dahlke, L. J., & Krom, R. A. F. (1994). FK506‐induced neurotoxicity in liver transplantation. Annals of Neurology. https://doi.org/10.1002/ana.410350422
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