The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains
Abstract
The amount of messenger RNA encoding human inducible nitric oxide synthase and the presence and distribution of NADPH diaphorase were determined in tissue sections from multiple sclerosis (MS) and control brains. Levels of human nitric oxide synthase messenger RNA were markedly elevated in MS brains when compared to normal control brains. NADPH diaphorase activity, a histochemical stain reflecting nitric oxide synthase catalytic activity, was detected in reactive astrocytes in active demyelinating MS lesions and at the edge of chronic active demyelinating lesions. Control brains did not contain NADPH diaphorase–positive astrocytes. These results implicate the free radical nitric oxide in the pathogenesis of demyelinating MS lesions.
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Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
NITRIC OXIDE: A Physiologic Messenger Molecule
Bredt, D. S., & Snyder, S. H. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.001135 · Cited by 2,368
Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages
Xie, Q.-W., Cho, H. J., Calaycay, J., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A., Troso, T., & Nathan, C. (1992) · Science · doi:10.1126/science.1373522 · Cited by 1,886
Handbook of clinical neurology
(1986) · Journal of Neuroimmunology · doi:10.1016/0165-5728(86)90030-5 · Cited by 1,849
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.
Dawson, T. M., Bredt, D. S., Fotuhi, M., Hwang, P. M., & Snyder, S. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7797 · Cited by 1,843
Self-citationBredt, D. S., Glatt, C. E., Hwang, P. M., Fotuhi, M., Dawson, T. M., & Snyder, S. H. (1991) · Neuron · doi:10.1016/0896-6273(91)90374-9 · Cited by 1,359
Self-citationNitric oxide synthase structure and mechanism
Marletta, M. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31375-9 · Cited by 1,338
Targeted disruption of the neuronal nitric oxide synthase gene
Huang, P. L., Dawson, T. M., Bredt, D. S., Snyder, S. H., & Fishman, M. C. (1993) · Cell · doi:10.1016/0092-8674(93)90615-w · Cited by 1,303
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Cited by
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Self-citationImmunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Self-citationLoss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
Zrzavy, T., Hametner, S., Wimmer, I., Butovsky, O., Weiner, H. L., & Lassmann, H. (2017) · Brain · doi:10.1093/brain/awx113 · Cited by 684
Offen, D., Gilgun-Sherki, Y., & Melamed, E. (2004) · Journal of Neurology · doi:10.1007/s00415-004-0348-9 · Cited by 638
Metadata
- Authors
- Bö, L., Dawson, T. M., Wesselingh, S., Möurk, S., Choi, S., Kong, P. A., Hanley, D., & Trapp, B. D.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1994-11
- Volume
- 36
- Issue
- 5
- Pages
- 778-786
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2079982783
- Cited by
- 567
- References
- 43
- FWCI
- 23.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Bö, L., Dawson, T. M., Wesselingh, S., Möurk, S., Choi, S., Kong, P. A., Hanley, D., & Trapp, B. D. (1994). Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Annals of Neurology. https://doi.org/10.1002/ana.410360515
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
