The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The role of spreading depression in focal ischemia evaluated bv dffusion mapping
Abstract
This study investigated the role of spontaneous and induced spreading depression (SD) on the evolution of focal ischemia in vivo. We induced focal ischemia in 12 rats using the middle cerebral artery suture occlusion (MCAO) method. Chemical stimulation of nonischemic ipsilateral cortex by potassium chloride application (KCl group; n = 7) and saline (NaCI group; n = 5) was performed at 15, 30, 45, and 60 minutes following MCAO, and SD was detected electrophysiologically. Ischemic lesion volumes assessed over 15‐minute intervals, evaluated by continuous apparent diffusion coefficient (ADC) of water mapping, demonstrated that the ischemic region increased significantly during 15‐minute time epochs with a single SD episode (36.5 ± 12.9 mm 3 mean ± SD) or multiple SD episodes (39.8 ± 22.3) compared with those without SD (13.9 ± 11.5) (p = 0.0009). Infarct volume at postmortem 24 hours after MCAO was significantly larger in the KCl group, with more total SDs (237.8 ± 13.8) than the NaCl group (190.5 ± 12.6) (p = 0.0001). This study demonstrates that ischemia‐related and induced SDs increase significantly ischemic lesion volume in vivo, supporting the hypothesis for a causative role of SD in extending focal ischemic injury.
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Citations
Cites
Viability thresholds and the penumbra of focal ischemia
Hossmann, K. (1994) · Annals of Neurology · doi:10.1002/ana.410360404 · Cited by 1,370
Fast magnetic resonance diffusion-weighted imaging of acute human stroke
Warach, S., Chien, D., Li, W., Ronthal, M., & Edelman, R. R. (1992) · Neurology · doi:10.1212/wnl.42.9.1717 · Cited by 881
Cited by
Dreier, J. P. (2011) · Nature Medicine · doi:10.1038/nm.2333 · Cited by 1,132
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature
Ayata, C., & Lauritzen, M. (2015) · Physiological Reviews · doi:10.1152/physrev.00027.2014 · Cited by 555
Fabricius, M., Fuhr, S., Bhatia, R., Boutelle, M., Hashemi, P., Strong, A. J., & Lauritzen, M. (2006) · Brain · doi:10.1093/brain/awh716 · Cited by 420
Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions
Nakamura, H., Strong, A. J., Dohmen, C., Sakowitz, O. W., Vollmar, S., Sué, M., Kracht, L., Hashemi, P., Bhatia, R., Yoshimine, T., et al. (2010) · Brain · doi:10.1093/brain/awq117 · Cited by 212
Rogatsky, G. G., Sonn, J., Kamenir, Y., Zarchin, N., & Mayevsky, A. (2003) · Journal of Neurotrauma · doi:10.1089/089771503322686111 · Cited by 60
Metadata
- Authors
- Takano, K., Latour, L. L., Formato, J. E., Carano, R. A. D., Helmer, K. G., Hasegawa, Y., Sotak, C. H., & Fisher, M.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1996-03
- Volume
- 39
- Issue
- 3
- Pages
- 308-318
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2083031870
- Cited by
- 238
- References
- 2
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
