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The response to levodopa in parkinson's disease: Imposing pharmacological law and order
Open accessAbstract
The seemingly unpredictable response to levodopa in patients with Parkinson's disease can be understood as an interaction between several distinct pharmacological effects of levodopa. The most important are a short‐duration response with a half‐life of minutes to hours and a long‐duration response with a half‐life of days, superimposed on diurnal motor variation. A negative response characterized by brief worsening before and after the short‐duration response and dyskinesia accentuate the short‐duration response. These various responses are modified by disease progression and long‐term levodopa therapy. Pharmacodynamic modeling of the short‐duration response indicates that with time, the response becomes less graded and small changes in levodopa concentrations can produce big changes in response. In this setting, unpredictability arises from the variation in absorption and distribution of levodopa.
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Nutt, J. G., Woodward, W. R., Carter, J. H., & Trotman, T. L. (1989) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.4.481 · Cited by 49
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Giovannoni, G. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.4.423 · Cited by 587
Levodopa in the treatment of Parkinson's disease: Current controversies
Olanow, C. W., Agid, Y., Mizuno, Y., Albanese, A., Bonucelli, U., Damier, P., De Yebenes, J., Gershanik, O., Guttman, M., Grandas, F., et al. (2004) · Movement Disorders · doi:10.1002/mds.20243 · Cited by 370
Helicobacter pylori infection and motor fluctuations in patients with Parkinson's disease
Lee, W. Y., Yoon, W. T., Shin, H. Y., Jeon, S. H., & Rhee, P. (2008) · Movement Disorders · doi:10.1002/mds.22190 · Cited by 110
Diurnal motor variations to repeated doses of levodopa in Parkinson's disease
Bonuccelli, U., Del Dotto, P., Lucetti, C., Petrozzi, L., Bernardini, S., Gambaccini, G., Rossi, G., & Piccini, P. (2000) · Clinical Neuropharmacology · doi:10.1097/00002826-200001000-00006 · Cited by 79
Metadata
- Authors
- Nutt, J. G., & Holford, N. H. G.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1996-05
- Volume
- 39
- Issue
- 5
- Pages
- 561-573
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2034770217
- Cited by
- 299
- References
- 1
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Nutt, J. G., & Holford, N. H. G. (1996). The response to levodopa in parkinson's disease: Imposing pharmacological law and order. Annals of Neurology. https://doi.org/10.1002/ana.410390504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
