The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Altered expression of bcl‐2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
Abstract
One of the primary neurodegenerative events occurring in amyotrophic lateral sclerosis (ALS) is the selective loss of spinal cord α motor neurons. To study the potential role of apoptosis in the degeneration of these motor neurons, in situ hybridization was used to measure the expression of two apoptotic cell death genes, bcl‐2 and bax, in control and ALS lumbar spinal cord sections. The strongest hybridization signal for bcl‐2 mRNA in neurological and nonneurological control spinal cords was found primarily in lamina IX α motor neurons, while a weaker hybridization signal was found in neurons of Clarke's nucleus and the proper sensory nucleus of the dorsal horn. Surviving lamina IX motor neurons in ALS spinal cord sections also expressed bcl‐2 mRNA, but at levels that were significantly and selectively decreased (4.7‐fold) compared with control. bax mRNA hybridization signal was detected in several cells throughout the gray matter in control and ALS lumbar spinal cord, but was significantly and selectively increased (2.8‐fold) in ALS motor neurons. Given the proposed interactive roles of these genes in apoptosis, the present findings favor a scenario in which this mode of cell death would contribute to spinal cord motor neuron degeneration in ALS.
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Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003
Cited by
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
Boillée, S., Vande Velde, C., & Cleveland, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.018 · Cited by 1,429
Molecular mechanisms of cell death in neurological diseases
Moujalled, D., Strasser, A., & Liddell, J. R. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-021-00814-y · Cited by 749
The role of neuronal growth factors in neurodegenerative disorders of the human brain
Connor, B., & Dragunow, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00004-6 · Cited by 536
Reed, J. C. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401975 · Cited by 473
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy
Vogler, M., Braun, Y., Smith, V. M., Westhoff, M.-A., Pereira, R. S., Pieper, N. M., Anders, M., Callens, M., Vervliet, T., Abbas, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02176-0 · Cited by 462
Metadata
- Authors
- Mu, X., He, J., Anderson, D. W., Springer, J. E., & Trojanowski, J. Q.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1996-09
- Volume
- 40
- Issue
- 3
- Pages
- 379-386
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1999261266
- Cited by
- 182
- References
- 2
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mu, X., He, J., Anderson, D. W., Springer, J. E., & Trojanowski, J. Q. (1996). Altered expression of bcl‐2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons. Annals of Neurology. https://doi.org/10.1002/ana.410400307
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