A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele
Abstract
There is a subset of very elderly patients with senile dementia in whom abundant neurofibrillary tangles are present, mainly in the hippocampal region, without a significant number of senile plaques. In a retrospective neuropathological examination of 239 dementia patients, 14 were found to have this type of senile dementia. The apolipoprotein E ϵ2, ϵ3, and ϵ4 allele frequencies in this patient group were 0.39, 0.50, and 0.11, respectively. Such a high frequency of the ϵ2 allele suggests that this type of dementia is distinct from Alzheimer's disease not only from a neuropathological but also from a genetic viewpoint.
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APOE ε2 is associated with increased pathological tau levels in the presence of amyloid.
“In addition, APOE ε2 is also associated with increased pathological tau levels in the presence of amyloid [471, 472].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [472]
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References 22 · Cited by 55
- Authors
- Ikeda, K., Akiyama, H., Arai, T., Sahara, N., Mori, H., Usami, M., Sakata, M., Mizutani, T., Wakabayashi, K., & Takahashi, H.
- Affiliations
- Tokyo Institute of Psychiatry (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Brain Research Institute, Niigata University (JP)
- Corresponding author
- Ikeda, Kenji
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1997-05
- Volume
- 41
- Issue
- 5
- Pages
- 693-695
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1967555823
- Cited by
- 55
- References
- 22
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2015: 1 · 2014: 2 · 2012: 2
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- senile dementia, neurofibrillary tangles, hippocampus, amyloid plaques, Alzheimer's disease, genetic susceptibility, allele frequency, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Apolipoproteins E, Dementia, Gene Frequency, Genotype, Gliosis, Hippocampus, Humans, Retrospective Studies, Neurofibrillary Tangles, Apolipoprotein E2
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