Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease
Abstract
We conducted cognitive, imaging, and neuropathological studies on a patient with Pick's disease. The patient was impaired at interpreting sentences with complex grammatical constructions, differing significantly from control subjects and patients with Alzheimer's disease (AD). Evaluation of regional brain functioning at rest, with positron emission tomography, revealed reduced left frontal activity compared with control subjects and AD patients. Autopsy demonstrated the classic pathology of Pick's disease, including massive neuron loss and gliosis in the frontal and cingulate cortex as well as numerous tau‐positive hippocampal Pick bodies. The abnormal tau proteins were phosphorylated at the same amino acid residues as AD paired helical filament tau (PHFtau), but they exhibited a unique migration profile on western blot. Our observations support the hypothesis that a distinct variety of hyperphosphorylated tau in Pick's disease compromises the long‐term viability of selectively vulnerable populations of neurons in frontal cortices that contribute to sentence processing.
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Structural MRI studies have shown that NFT deposition is associated with grey matter atrophy resulting from neurodegeneration, and that different tauopathies display distinctive regional patterns of grey matter atrophy.
“Structural MRI studies have shown that NFT deposition is associated with grey matter atrophy that results from neurodegeneration and that different tauopathies display distinctive regional patterns of grey matter atrophy [5][6][7][8].”
From Diffusion tensor imaging reveals whole-brain microstructural changes in the P301L mouse model of tauopathy. (2020) · cites this paper as [5]
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- Authors
- Lieberman, A. P., Trojanowski, J. Q., Lee, V. M. ‐., Balin, B. J., Ding, X., Greenberg, J., Morrison, D., Reivich, M., & Grossman, M.
- Affiliations
- University of Pennsylvania Health System (US)
- University of Pennsylvania (US)
- Corresponding author
- Grossman, Murray
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1998-02
- Volume
- 43
- Issue
- 2
- Pages
- 259-265
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1995104138
- Cited by
- 54
- References
- 0
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG15116, R01AG015116)
- National Institute of Neurological Disorders and Stroke (R01NS035867, NS35867, NS 14867)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- Pick's disease, Pick bodies, tau hyperphosphorylation, sentence processing, left frontal cortex, Alzheimer's disease comparison, cingulate cortex, gliosis, positron emission tomography, neuroimaging, neuropathology
- MeSH terms
- Aged, Amygdala, Atrophy, Cerebral Cortex, Cerebrovascular Circulation, Cognition Disorders, Dementia, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Microscopy, Electron, Neurofibrils, Neurons, Tomography, Emission-Computed, tau Proteins, Fatal Outcome, Dentate Gyrus
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