Nichtenzymatische Oligomerisierung von Ribonucleotiden an guanosinreichen Matrizen: Unterdrückung der Selbstpaarung von Guanosin
Abstract
Acridinmarkierte Primer erwiesen sich als wertvolles Instrument zum Studium der matrizengesteuerten Oligomerisierung von RNA (unten schematisch dargestellt). Mit ihrer Hilfe wurden Bedingungen für den effizienten Einbau von Cytidin gefunden. Die Aggregation guanosinreicher Matrizen, bislang ein Haupthindernis für die nichtenzymatische Selbstreplikation von RNA, wird hierbei auf ein Minimum reduziert.magnified image
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Activated A and U monomers are added to a primer much more slowly than activated G or C monomers.
“2-Methylimidazole-activated AMP or UMP (2-MeImpA or 2-MeImpU)9 are added to the 3′-end of a primer (annealed to a complementary template) at a much slower rate than 2-MeImpG or 2-MeImpC.10−12”
From Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension (2015) · cites this paper as [11]
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References 38 · Cited by 15
- Authors
- Kurz, M., Göbel, K., Hartel, C., & Göbel, M. W.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Göbel, Michael W.
- ORCID
- Göbel, Michael W.
- Venue
- Angewandte Chemie
- Publisher
- Wiley
- Published
- 1997-04-18
- Volume
- 109
- Issue
- 8
- Pages
- 873-876
- ISSN
- 0044-8249 (ISSN-L)
- 1521-3757
- OpenAlex
- W1982340660
- Cited by
- 15
- References
- 38
- Citations by year
- 2018: 3 · 2015: 1 · 2012: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- cytidine incorporation, RNA self-replication
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