An Epigenetics‐Inspired DNA‐Based Data Storage System
Open accessAbstract
Biopolymers are an attractive alternative to store and circulate information. DNA, for example, combines remarkable longevity with high data storage densities and has been demonstrated as a means for preserving digital information. Inspired by the dynamic, biological regulation of (epi)genetic information, we herein present how binary data can undergo controlled changes when encoded in synthetic DNA strands. By exploiting differential kinetics of hydrolytic deamination reactions of cytosine and its naturally occurring derivatives, we demonstrate how multiple layers of information can be stored in a single DNA template. Moreover, we show that controlled redox reactions allow for interconversion of these DNA‐encoded layers of information. Overall, such interlacing of multiple messages on synthetic DNA libraries showcases the potential of chemical reactions to manipulate digital information on (bio)polymers.
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Beyond random access, other file operations such as encryption with genomic keys, erasure on the basis of obfuscation, and rewriting by chemical modification or PCR are also supported by sequence-based DNA data storage.
“Beyond random access, other file operations such as encryption with genomic keys,79 erasure on the basis of obfuscation,80 and rewriting by chemical modification or PCR81,82 are also supported by sequence-based DNA data storage.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [82]
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References 37 · Cited by 19
Research works printed but not linked: 2
- M. Munzel, D. Globisch,C .T rindler,T .C arell, Org.L ett. 2010, 12,5 671 -5673.
- J .F .L utz, M. Ouchi, D. R. Liu, M. Sawamoto, Science 2013, 341,6 28.
- Authors
- Mayer, C., McInroy, G. R., Murat, P., Van Delft, P., & Balasubramanian, S.
- Affiliations
- University of Cambridge (GB)
- Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK
- Corresponding author
- Balasubramanian, Shankar
- Venue
- Angewandte Chemie
- Publisher
- Wiley
- Published
- 2016-07-21
- Volume
- 128
- Issue
- 37
- Pages
- 11310-11314
- ISSN
- 0044-8249 (ISSN-L)
- 1521-3757
- OpenAlex
- W4230868487
- Cited by
- 19
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Angewandte Chemie (publishedVersion, cc-by)
- Funders
- National Science Foundation (P2EZP2_152216)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNA data storage, synthetic DNA, cytosine deamination, redox reactions
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