The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Conformation and Biological Activity of Cyclic Peptides
Abstract
Cyclic peptides containing biologically active hormone sequences are suitable models for studying conformation‐activity relationships. In such models the usual flexibility of peptide chains is reduced by their cyclic arrangement. However, conformational analysis of such systems by experimental means is possible only if a single conformer predominates at equilibrium, and criteria for this are put forward. NMR spectroscopic methods, including many recent advances, are discussed in relation to their ability to contribute to peptide conformational analysis.
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Citations
Cites
Influence of the Distance of the Proline Carbonyl from the β and γ Carbon on the 13C Chemical Shifts
Siemion, I. Z., Wieland, T., & Pook, K. (1975) · Angewandte Chemie International Edition in English · doi:10.1002/anie.197507021 · Cited by 176
Cited by
N-Methylation of Peptides: A New Perspective in Medicinal Chemistry
Chatterjee, J., Gilon, C., Hoffman, A., & Kessler, H. (2008) · Accounts of Chemical Research · doi:10.1021/ar8000603 · Cited by 577
Self-citationImproving Oral Bioavailability of Peptides by Multiple N‐Methylation: Somatostatin Analogues
Biron, E., Chatterjee, J., Ovadia, O., Langenegger, D., Brueggen, J., Hoyer, D., Schmid, H. A., Jelinek, R., Gilon, C., Hoffman, A., et al. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200705797 · Cited by 374
Self-citationDesigning peptide receptor agonists and antagonists
Hruby, V. J. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd939 · Cited by 344
Chorev, M., Roubini, E., McKee, R. L., Gibbons, S. W., Goldman, M. E., Caulfield, M. P., & Rosenblatt, M. (1991) · Biochemistry · doi:10.1021/bi00238a022 · Cited by 107
Murail, S., Sawmynaden, J., Zemirli, A., Jusot, M., Pietrucci, F., Chomilier, J., Tufféry, P., & Stratmann, D. (2025) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.5c01123 · Cited by 6
Metadata
- Authors
- Kessler, H.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1982-07
- Volume
- 21
- Issue
- 7
- Pages
- 512-523
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2146088099
- Cited by
- 868
- References
- 1
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kessler, H. (1982). Conformation and Biological Activity of Cyclic Peptides. Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.198205121
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
