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Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis
Abstract
This account examines double asymmetric induction from theoretical and practical viewpoints. In the context of four major organic reactions‐the aldol, Diels‐Alder, catalytic hydrogenation, and epoxidation‐it is shown that a double asymmetric induction can be analyzed in terms of the single asymmetric reactions of each of the two chiral reactants. A rule which qualitatively relates the results of these single asymmetric reactions with the outcome of the double asymmetric reaction is proposed. A powerful new strategy based on this rule for the predictable creation of new chiral centers is discussed and the use of this strategy for the synthesis of sugars and macrolides is presented.
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Citations
Cited by
Kagan, H. B., & Fiaud, J. C. (1988) · Topics in Stereochemistry · doi:10.1002/9780470147276.ch4 · Cited by 992
Müller, D., Pitsch, S., Kittaka, A., Wagner, E., Wintner, C. E., Eschenmoser, A., & Ohlofjgewidmet, G. (1990) · Helvetica Chimica Acta · doi:10.1002/hlca.19900730526 · Cited by 216
Metadata
- Authors
- Masamune, S., Choy, W., Petersen, J. S., & Sita, L. R.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1985-01
- Volume
- 24
- Issue
- 1
- Pages
- 1-30
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W1994781879
- Cited by
- 1,091
- References
- 0
- FWCI
- 48.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis. https://app.cochat.ai/papers/10.1002/anie.198500013
- The paper
- Masamune, S., Choy, W., Petersen, J. S., & Sita, L. R. (1985). Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis. Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.198500013
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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